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    UCP2 uncoupling protein 2 [ Canis lupus familiaris (dog) ]

    Gene ID: 403576, updated on 17-Aug-2024

    Summary

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    Official Symbol
    UCP2provided by VGNC
    Official Full Name
    uncoupling protein 2provided by VGNC
    Primary source
    VGNC:VGNC:48111
    See related
    Ensembl:ENSCAFG00845007207
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See UCP2 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 21 NC_051825.1 (24510583..24517796)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 21 NC_006603.4 (24075387..24078118)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 21 NC_049242.1 (24425514..24428245)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 21 NC_049281.1 (24310265..24312996)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 21 NC_049762.1 (24510181..24512912)

    Chromosome 21 - NC_051825.1Genomic Context describing neighboring genes Neighboring gene uncoupling protein 3 Neighboring gene protein FAM91A1-like Neighboring gene DnaJ heat shock protein family (Hsp40) member B13 Neighboring gene uncharacterized LOC119864978 Neighboring gene tetraspanin-3-like Neighboring gene proteasomal ATPase associated factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Role of Uncoupling Protein 2 During Myocardial Dysfunction in a Canine Model of Endotoxin Shock. Wang X, et al. Shock, 2015 Mar. PMID 25526378
    2. Canine mitochondrial uncoupling proteins: structure and mRNA expression of three isoforms in adult beagles. Ishioka K, et al. Comp Biochem Physiol B Biochem Mol Biol, 2002 Mar. PMID 11959030

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. UCP2 protein and mRNA levels were negatively correlated with myocardial energy levels in a model of endotoxic shock
      Title: The Role of Uncoupling Protein 2 During Myocardial Dysfunction in a Canine Model of Endotoxin Shock.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables oxidative phosphorylation uncoupler activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adaptive thermogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mitochondrial transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mitochondrial transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to cold IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dicarboxylate carrier UCP2; mitochondrial uncoupling protein 2
    Names
    UCP 2
    dicarboxylate carrier SLC25A8
    solute carrier family 25 member 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003048.1 → NP_001003048.1  dicarboxylate carrier UCP2

      See identical proteins and their annotated locations for NP_001003048.1

      Status: PROVISIONAL

      Source sequence(s)
      AB020887
      UniProtKB/Swiss-Prot
      Q9N2J1, Q9TTT0
      Conserved Domains (2) summary
      PTZ00169
      Location:17 → 299
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:112 → 206
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051825.1 Reference ROS_Cfam_1.0

      Range
      24510583..24517796
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038429438.1 → XP_038285366.1  mitochondrial uncoupling protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0JML0, A0A8C0NJ47, F1PWF8
      Related
      ENSCAFP00845009964.1, ENSCAFT00845012776.1
      Conserved Domains (1) summary
      pfam00153
      Location:112 → 206
      Mito_carr; Mitochondrial carrier protein

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049281.1 Alternate UMICH_Zoey_3.1

      Range
      24310265..24312996
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049762.1 Alternate UNSW_CanFamBas_1.0

      Range
      24510181..24512912
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049242.1 Alternate UU_Cfam_GSD_1.0

      Range
      24425514..24428245
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006603.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      24075387..24078118
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9N2J1.1 GenPept UniProtKB/Swiss-Prot:Q9N2J1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials