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    UCP1 uncoupling protein 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 403574, updated on 5-Mar-2024

    Summary

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    Gene symbol
    UCP1
    Gene description
    uncoupling protein 1
    See related
    Ensembl:ENSCAFG00845020627
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See UCP1 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 19 NC_051823.1 (2346071..2354913)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 19 NC_006601.4 (2528227..2536537)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 19 NC_049240.1 (3000436..3008747)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 19 NC_049279.1 (2283269..2291546)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 19 NC_049760.1 (2644470..2652732)

    Chromosome 19 - NC_051823.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111091043 Neighboring gene TBC1 domain family member 9 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC106560034 Neighboring gene ELMO domain containing 2 Neighboring gene MGAT4 family member D Neighboring gene uncharacterized LOC119864430

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of uncoupling protein 1 in the anti-obesity effect of beta3-adrenergic agonist in the dog. Omachi A, et al. Res Vet Sci, 2008 Oct. PMID 18406437
    2. Canine mitochondrial uncoupling proteins: structure and mRNA expression of three isoforms in adult beagles. Ishioka K, et al. Comp Biochem Physiol B Biochem Mol Biol, 2002 Mar. PMID 11959030
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables oxidative phosphorylation uncoupler activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adaptive thermogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mitochondrial transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mitochondrial transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to cold IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitochondrial brown fat uncoupling protein 1
    Names
    UCP 1
    solute carrier family 25 member 7
    thermogenin
    uncoupling protein 1 UCP1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003046.1 → NP_001003046.1  mitochondrial brown fat uncoupling protein 1

      See identical proteins and their annotated locations for NP_001003046.1

      Status: PROVISIONAL

      Source sequence(s)
      AB046106
      UniProtKB/Swiss-Prot
      Q9GMZ1
      Conserved Domains (2) summary
      PTZ00169
      Location:33 → 299
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:114 → 207
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051823.1 Reference ROS_Cfam_1.0

      Range
      2346071..2354913
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038425559.1 → XP_038281487.1  mitochondrial brown fat uncoupling protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0S0M6, A0A8I3S4I6
      Related
      ENSCAFP00845028509.1, ENSCAFT00845036422.1
      Conserved Domains (1) summary
      pfam00153
      Location:114 → 207
      Mito_carr; Mitochondrial carrier protein

    2. XM_038425558.1 → XP_038281486.1  mitochondrial brown fat uncoupling protein 1 isoform X1

      Conserved Domains (1) summary
      pfam00153
      Location:113 → 206
      Mito_carr; Mitochondrial carrier protein

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049279.1 Alternate UMICH_Zoey_3.1

      Range
      2283269..2291546
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049760.1 Alternate UNSW_CanFamBas_1.0

      Range
      2644470..2652732
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049240.1 Alternate UU_Cfam_GSD_1.0

      Range
      3000436..3008747
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006601.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      2528227..2536537
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9GMZ1.1 GenPept UniProtKB/Swiss-Prot:Q9GMZ1

    Gene LinkOut

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    Research Materials