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    TPMT thiopurine S-methyltransferase [ Canis lupus familiaris (dog) ]

    Gene ID: 403536, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TPMTprovided by VGNC
    Official Full Name
    thiopurine S-methyltransferaseprovided by VGNC
    Primary source
    VGNC:VGNC:47745
    See related
    Ensembl:ENSCAFG00845028681
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See TPMT in Genome Data Viewer
    Location:
    chromosome: 35
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 35 NC_051839.1 (17035847..17060453, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 35 NC_006617.4 (16879116..16902874, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 35 NC_049256.1 (18237408..18261325, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 35 NC_049295.1 (16849193..16872898, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 35 NC_049776.1 (16906511..16930057, complement)

    Chromosome 35 - NC_051839.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119867623 Neighboring gene NHL repeat containing E3 ubiquitin protein ligase 1 Neighboring gene lysine demethylase 1B Neighboring gene U6 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Canine red blood cell thiopurine S-methyltransferase: companion animal pharmacogenetics. Salavaggione OE, et al. Pharmacogenetics, 2002 Dec. PMID 12464800

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables thiopurine S-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    thiopurine S-methyltransferase
    Names
    thiopurine methyltransferase
    NP_001003015.1
    XP_038302067.1
    XP_038302068.1
    XP_038302069.1
    XP_038302070.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003015.2 → NP_001003015.1  thiopurine S-methyltransferase

      See identical proteins and their annotated locations for NP_001003015.1

      Status: PROVISIONAL

      Source sequence(s)
      AY057077
      UniProtKB/Swiss-Prot
      Q8HX86
      UniProtKB/TrEMBL
      A0A8C0KC33, A0A8C0TKK4
      Conserved Domains (1) summary
      pfam05724
      Location:24 → 245
      TPMT; Thiopurine S-methyltransferase (TPMT)

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051839.1 Reference ROS_Cfam_1.0

      Range
      17035847..17060453 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038446141.1 → XP_038302069.1  thiopurine S-methyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q8HX86
      UniProtKB/TrEMBL
      A0A8C0KC33, A0A8C0TKK4
      Conserved Domains (1) summary
      pfam05724
      Location:24 → 245
      TPMT; Thiopurine S-methyltransferase (TPMT)

    2. XM_038446142.1 → XP_038302070.1  thiopurine S-methyltransferase isoform X2

      UniProtKB/TrEMBL
      A0A8C0TKK4
      Conserved Domains (1) summary
      pfam05724
      Location:24 → 230
      TPMT; Thiopurine S-methyltransferase (TPMT)

    3. XM_038446139.1 → XP_038302067.1  thiopurine S-methyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q8HX86
      UniProtKB/TrEMBL
      A0A8C0KC33, A0A8C0TKK4
      Conserved Domains (1) summary
      pfam05724
      Location:24 → 245
      TPMT; Thiopurine S-methyltransferase (TPMT)

    4. XM_038446140.1 → XP_038302068.1  thiopurine S-methyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q8HX86
      UniProtKB/TrEMBL
      A0A8C0KC33, A0A8C0TKK4
      Related
      ENSCAFP00845039735.1, ENSCAFT00845050687.1
      Conserved Domains (1) summary
      pfam05724
      Location:24 → 245
      TPMT; Thiopurine S-methyltransferase (TPMT)

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049295.1 Alternate UMICH_Zoey_3.1

      Range
      16849193..16872898 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049776.1 Alternate UNSW_CanFamBas_1.0

      Range
      16906511..16930057 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049256.1 Alternate UU_Cfam_GSD_1.0

      Range
      18237408..18261325 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006617.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      16879116..16902874 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8HX86.1 GenPept UniProtKB/Swiss-Prot:Q8HX86

    Gene LinkOut

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