SERPINE1 serpin family E member 1 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: SERPINE1provided by VGNC
Official Full Name: serpin family E member 1provided by VGNC
Primary source: VGNC:VGNC:46036
See related: Ensembl:ENSCAFG00845000607
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: PAI-1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	6	NC_051810.1 (8538810..8546429, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	6	NC_006588.4 (10418147..10423482, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	6	NC_049227.1 (8635341..8640693, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	6	NC_049266.1 (8500159..8505509, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	6	NC_049747.1 (8470611..8475963, complement)

Chromosome 6 - NC_051810.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PAI-1 activity was increased in hyperlipidemic compared to healthy dogs, but there was no significant difference between dogs with hyperadrenocorticism and diabetes mellitus.
Title: Development of a plasminogen activator inhibitor (PAI-1) assay and comparison of plasma PAI-1 activity in hyperlipidemic/dyslipidemic dogs with either hyperadrenocorticism or diabetes mellitus, and healthy dogs.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of plasminogen activation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of vascular wound healing	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: plasminogen activator inhibitor 1

Names: plasminogen activator inhibitor type 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001197095.2 → NP_001184024.1 plasminogen activator inhibitor 1 precursor

See identical proteins and their annotated locations for NP_001184024.1

Status: VALIDATED

Source sequence(s)

JAAUVH010000065

UniProtKB/TrEMBL

A0A8C0PBU3, A0A8C0R0I1, A0A8C0SB04, A0A8I3MDS4

Conserved Domains (1) summary

cl38926
Location:30 → 402

serpin; SERine Proteinase INhibitors (serpin) family

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051810.1 Reference ROS_Cfam_1.0

Range

8538810..8546429 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038667550.1 → XP_038523478.1 plasminogen activator inhibitor 1 isoform X1

UniProtKB/TrEMBL

A0A8C0PBU3, A0A8C0R0I1, A0A8C0SB04, A0A8I3MDS4

Related

ENSCAFP00845000755.1, ENSCAFT00845000996.1

Conserved Domains (1) summary

cl38926
Location:30 → 402

serpin; SERine Proteinase INhibitors (serpin) family
XM_038667551.1 → XP_038523479.1 plasminogen activator inhibitor 1 isoform X1

UniProtKB/TrEMBL

A0A8C0PBU3, A0A8C0R0I1, A0A8C0SB04, A0A8I3MDS4

Conserved Domains (1) summary

cl38926
Location:30 → 402

serpin; SERine Proteinase INhibitors (serpin) family