U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    GJA1 gap junction protein alpha 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 403418, updated on 17-Aug-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    GJA1provided by VGNC
    Official Full Name
    gap junction protein alpha 1provided by VGNC
    Primary source
    VGNC:VGNC:41231
    See related
    Ensembl:ENSCAFG00845009132
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    cx43
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See GJA1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (61130176..61143784)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (61750272..61753194)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (61515138..61518103)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (61052769..61055708)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (60868101..60871024)

    Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111096171 Neighboring gene TBC1 domain family member 32 Neighboring gene uncharacterized LOC102157283 Neighboring gene uncharacterized LOC119870673 Neighboring gene peptidyl-prolyl cis-trans isomerase A-like

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Mechanisms underlying conduction slowing and arrhythmogenesis in nonischemic dilated cardiomyopathy. Akar FG, et al. Circ Res, 2004 Oct 1. PMID 15345654
    2. Connexin 43 reduces susceptibility to sympathetic atrial fibrillation. Luo B, et al. Int J Mol Med, 2018 Aug. PMID 29717772
    3. Connexin43 PDZ2 binding domain mutants create functional gap junctions and exhibit altered phosphorylation. Jin C, et al. Cell Commun Adhes, 2004 Mar-Aug. PMID 16247852, Free PMC Article
    4. Changes in connexin 43, metalloproteinase and tissue inhibitor of metalloproteinase during tachycardia-induced cardiomyopathy in dogs. Zhong JQ, et al. Eur J Heart Fail, 2007 Jan. PMID 16828340
    5. Cloning of GJA1 (connexin43) and its expression in canine ovarian follicles throughout the estrous cycle. Willingham-Rocky LA, et al. Gene Expr Patterns, 2007 Jan. PMID 16829210

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gene and protein expression of connexins 37 and 43 in cumulus-oocytes complexes throughout the canine oestrous cycle.
      Title: Gene and protein expression of connexins 37 and 43 in cumulus-oocytes complexes throughout the canine oestrous cycle.
    2. The results of the present study suggest that Cx43 reduces susceptibility to atrial fibrillation.
      Title: Connexin 43 reduces susceptibility to sympathetic atrial fibrillation.
    3. increased acetylation of Cx43 in the left ventricles of dogs subjected to chronic tachypacing as abnormal ventricular activation... altered electrical activity can regulate cardiomyocyte communication by influencing the acetylation status of Cx43
      Title: Acetylation mediates Cx43 reduction caused by electrical stimulation.
    4. the alteration of Cx43 and/or phosphorylated Cx43 levels and the imbalance of MMP-2 and TIMP-2 may contribute to the initiation and/or persistence of ventricular fibrillation.
      Title: Dynamic alterations of connexin43, matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase-2 during ventricular fibrillation in canine.
    5. Akt-dependent phosphorylation of Serine 373 increases gap junction size and communication by completely eliminating the interaction between Cx43 and ZO-1.
      Title: Injury-triggered Akt phosphorylation of Cx43: a ZO-1-driven molecular switch that regulates gap junction size.
    6. Cardiac pacing results in time-dependent changes in connexin43 expression, which may alter gap junction function and influence arrhythmia generation during a subsequent ischaemia/reperfusion insult.
      Title: The involvement of gap junctions in the delayed phase of the protection induced by cardiac pacing in dogs.
    7. An increase of myofibroblasts in the infarcted heart causes heterogeneous Cx43 levels, possibly as a result of the release of IL-1beta and decreased cell-cell communication, which leads to conduction abnormalities following infarction.
      Title: Myofibroblasts cause heterogeneous Cx43 reduction and are unlikely to be coupled to myocytes in the healing canine infarct.
    8. Cx43 ubiquitination is not necessary for the regulation of Cx43 turnover; rather, Akt activity, probably through direct phosphorylation of Cx43, controls gap junction stability.
      Title: Activation of Akt, not connexin 43 protein ubiquitination, regulates gap junction stability.
    9. All-trans retinoic acid significantly increased Cx43 expression and gap junction intercellular communication in canine lens epithelial cells (LEC), associated with increased cell differentiation.
      Title: All-trans retinoic Acid regulates cx43 expression, gap junction communication and differentiation in primary lens epithelial cells.
    10. Connexin 43 gap junctions with highly variable morphology are formed between cardiomyocyte lateral membranes with increased frequency in heart failure and GJ turnover likely occurs via an autophagic pathway.
      Title: Ultrastructure and regulation of lateralized connexin43 in the failing heart.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell-cell signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in heart development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of connexin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    gap junction alpha-1 protein
    Names
    gap junction protein, alpha 1, 43kDa (connexin 43)

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002951.3 → NP_001002951.2  gap junction alpha-1 protein

      Status: VALIDATED

      Source sequence(s)
      JAAUVH010000354
      UniProtKB/Swiss-Prot
      Q6S9C0
      UniProtKB/TrEMBL
      A0A654IEC4, A0A8C0LBI4, A0A8P0T9K9
      Conserved Domains (2) summary
      pfam00029
      Location:3 → 233
      Connexin
      pfam03508
      Location:293 → 312
      Connexin43; Gap junction alpha-1 protein (Cx43)

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051805.1 Reference ROS_Cfam_1.0

      Range
      61130176..61143784
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038653369.1 → XP_038509297.1  gap junction alpha-1 protein isoform X1

      UniProtKB/Swiss-Prot
      Q6S9C0
      UniProtKB/TrEMBL
      A0A654IEC4, A0A8C0LBI4, A0A8P0T9K9
      Related
      ENSCAFP00845012583.1, ENSCAFT00845016174.1
      Conserved Domains (2) summary
      pfam00029
      Location:3 → 233
      Connexin
      pfam03508
      Location:293 → 312
      Connexin43; Gap junction alpha-1 protein (Cx43)

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049261.1 Alternate UMICH_Zoey_3.1

      Range
      61052769..61055708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

      Range
      60868101..60871024
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

      Range
      61515138..61518103
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      61750272..61753194
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6S9C0.3 GenPept UniProtKB/Swiss-Prot:Q6S9C0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.