DNASE1 deoxyribonuclease 1 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: DNASE1provided by VGNC
Official Full Name: deoxyribonuclease 1provided by VGNC
Primary source: VGNC:VGNC:40023
See related: Ensembl:ENSCAFG00845002013
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	6	NC_051810.1 (37811866..37814684, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	6	NC_006588.4 (38925673..38928375, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	6	NC_049227.1 (37898900..37901602, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	6	NC_049266.1 (37595076..37597778, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	6	NC_049747.1 (37488193..37490895, complement)

Chromosome 6 - NC_051810.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

canine enzyme is more closely related to the human DNase I than to other mammalian DNases I
Title: Molecular, biochemical and immunological analyses of canine pancreatic DNase I.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA nuclease activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA catabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: deoxyribonuclease-1

Names: DNase I; deoxyribonuclease I

NP_001002946.1

EC 3.1.21.1

XP_038523476.1

EC 3.1.21.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002946.1 → NP_001002946.1 deoxyribonuclease-1 precursor

See identical proteins and their annotated locations for NP_001002946.1

Status: PROVISIONAL

Source sequence(s)

AB113380

UniProtKB/Swiss-Prot

Q767J3

UniProtKB/TrEMBL

A0A8C0LNB2, A0A8C0SVF9

Related

ENSCAFP00845002788.1, ENSCAFT00845003514.1

Conserved Domains (1) summary

smart00476
Location:24 → 282

DNaseIc; deoxyribonuclease I

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051810.1 Reference ROS_Cfam_1.0

Range

37811866..37814684 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038667548.1 → XP_038523476.1 deoxyribonuclease-1 isoform X1

UniProtKB/TrEMBL

A0A8C0SSS1, A0A8C0YZU9, A0A8I3MES6, A0A8I3MK02

Related

ENSCAFP00845002804.1, ENSCAFT00845003532.1

Conserved Domains (1) summary

cl00490
Location:24 → 376

EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily