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    SIGLEC1 sialic acid binding Ig like lectin 1 [ Sus scrofa (pig) ]

    Gene ID: 397623, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SIGLEC1provided by VGNC
    Official Full Name
    sialic acid binding Ig like lectin 1provided by VGNC
    Primary source
    VGNC:VGNC:108736
    See related
    Ensembl:ENSSSCG00000007146
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    SA; SN; pSn; p210; SIGLEC-1
    Expression
    Biased expression in lung (RPKM 34.5), spleen (RPKM 30.0) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See SIGLEC1 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 17 NC_010459.5 (31994505..32021239)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 17 NC_010459.4 (36328314..36347405)

    Chromosome 17 - NC_010459.5Genomic Context describing neighboring genes Neighboring gene sperm flagellar 1 Neighboring gene adipose secreted signaling protein Neighboring gene heat shock protein family A (Hsp70) member 12B Neighboring gene ADAM metallopeptidase domain 33 Neighboring gene GDNF family receptor alpha 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of the porcine sialoadhesin gene promoter region and its cell-specific expression in porcine alveolar macrophage cells. Sun W, et al. Genet Mol Res, 2014 Nov 14. PMID 25501171
    2. Analysis of the binding sites of porcine sialoadhesin receptor with PRRSV. Jiang Y, et al. Int J Mol Sci, 2013 Dec 9. PMID 24351868, Free PMC Article
    3. An intact sialoadhesin (Sn/SIGLEC1/CD169) is not required for attachment/internalization of the porcine reproductive and respiratory syndrome virus. Prather RS, et al. J Virol, 2013 Sep. PMID 23785195, Free PMC Article
    4. Antibody binding to porcine sialoadhesin reduces phagocytic capacity without affecting other macrophage effector functions. De Baere MI, et al. Cell Immunol, 2011. PMID 21944562
    5. Porcine reproductive and respiratory syndrome virus attachment is mediated by the N-terminal domain of the sialoadhesin receptor. An TQ, et al. Vet Microbiol, 2010 Jul 14. PMID 19969429

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the transcription initiation site for sialoadhesin (Siglec-1), which is a porcine alveolar macrophage-specific gene, was determined by 5' rapid amplification of cDNA end.
      Title: Identification of the porcine sialoadhesin gene promoter region and its cell-specific expression in porcine alveolar macrophage cells.
    2. Fusion protein of sialoadhesin and domains 5-9 of CD163 receptors blocked the respiratory syndrome virus infection.
      Title: Additive inhibition of porcine reproductive and respiratory syndrome virus infection with the soluble sialoadhesin and CD163 receptors.
    3. European genotype porcine reproductive and respiratory syndrome virus inhibits porcine alveolar macrophages phagocytosis in vitro, through the interaction with its internalization receptor sialoadhesin.
      Title: Interaction of the European genotype porcine reproductive and respiratory syndrome virus (PRRSV) with sialoadhesin (CD169/Siglec-1) inhibits alveolar macrophage phagocytosis.
    4. After infection, PRRSV viremia in SIGLEC1(-/-) pigs followed the same course as in SIGLEC1(-/+) and SIGLEC1(+/+) littermates. The absence of SIGLEC1 had no effect on other aspects of PRRSV infection, including disease course and histopathology.
      Title: An intact sialoadhesin (Sn/SIGLEC1/CD169) is not required for attachment/internalization of the porcine reproductive and respiratory syndrome virus.
    5. Endodomain-deletion mutants of sialoadhesin promoted porcine reproductive and respiratory syndrome virus infection less efficiently.
      Title: Porcine, murine and human sialoadhesin (Sn/Siglec-1/CD169): portals for porcine reproductive and respiratory syndrome virus entry into target cells.
    6. ). These results provided fundamental evidence for CD163 and SN as two functional candidate genes affecting immunity in pigs.
      Title: Association of two porcine reproductive and respiratory syndrome virus (PRRSV) receptor genes, CD163 and SN with immune traits.
    7. effect of antibody binding to pSn on macrophage viability, phagocytosis of microspheres, uptake and processing of soluble antigens, reactive oxygen/nitrogen species production, MHC I and MHC II cell surface expression and cytokine production
      Title: Antibody binding to porcine sialoadhesin reduces phagocytic capacity without affecting other macrophage effector functions.
    8. Porcine sialoadhesin (CD169/Siglec-1) is an endocytic receptor that allows targeted delivery of toxins and antigens to macrophages.
      Title: Porcine sialoadhesin (CD169/Siglec-1) is an endocytic receptor that allows targeted delivery of toxins and antigens to macrophages.
    9. The present study demonstrates that the first domain at the N-terminus of Sn mediates porcine reproductive and respiratory syndrome virus (PRRSV) attachment to macrophages.
      Title: Porcine reproductive and respiratory syndrome virus attachment is mediated by the N-terminal domain of the sialoadhesin receptor.
    10. Clear changes in the quantity of sialoadhesin(+) and CD163(+) macrophages in the placentas and organs of embryos/fetuses during gestation.
      Title: Quantitative changes of sialoadhesin and CD163 positive macrophages in the implantation sites and organs of porcine embryos/fetuses during gestation.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    General gene information

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    Homology

    General protein information

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    Preferred Names
    sialoadhesin
    Names
    Sialic acid-binding Ig-like lectin 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214346.1 → NP_999511.1  sialoadhesin precursor

      See identical proteins and their annotated locations for NP_999511.1

      Status: PROVISIONAL

      Source sequence(s)
      AF509585
      UniProtKB/TrEMBL
      J9S2W1, J9T303
      Related
      ENSSSCP00000034728.3, ENSSSCT00000035867.4
      Conserved Domains (7) summary
      cd00096
      Location:1004 → 1079
      Ig; Immunoglobulin domain
      smart00408
      Location:1458 → 1519
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:1004 → 1079
      IG; Immunoglobulin
      smart00410
      Location:516 → 594
      IG_like; Immunoglobulin like
      pfam07679
      Location:897 → 979
      I-set; Immunoglobulin I-set domain
      pfam13895
      Location:514 → 594
      Ig_2; Immunoglobulin domain
      cl11960
      Location:21 → 136
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010459.5 Reference Sscrofa11.1 Primary Assembly

      Range
      31994505..32021239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021077303.1 → XP_020932962.1  sialoadhesin isoform X1

      UniProtKB/TrEMBL
      A0A286ZYH0, A0A8D1ZN94
      Related
      ENSSSCP00000036684.2, ENSSSCT00000007819.5
      Conserved Domains (8) summary
      smart00408
      Location:254 → 312
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:1004 → 1079
      IG; Immunoglobulin
      smart00410
      Location:1092 → 1149
      IG_like; Immunoglobulin like
      pfam13895
      Location:338 → 408
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:710 → 774
      Ig_3; Immunoglobulin domain
      cd00096
      Location:1363 → 1437
      Ig; Immunoglobulin domain
      cl11960
      Location:21 → 136
      Ig; Immunoglobulin domain
      cl28434
      Location:806 → 892
      I-set; Immunoglobulin I-set domain

    2. XM_021077304.1 → XP_020932963.1  sialoadhesin isoform X2

      UniProtKB/TrEMBL
      A0A8D1ZN94
      Conserved Domains (8) summary
      smart00408
      Location:254 → 312
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:1003 → 1078
      IG; Immunoglobulin
      smart00410
      Location:1091 → 1148
      IG_like; Immunoglobulin like
      pfam13895
      Location:338 → 408
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:709 → 773
      Ig_3; Immunoglobulin domain
      cd00096
      Location:1362 → 1436
      Ig; Immunoglobulin domain
      cl11960
      Location:21 → 136
      Ig; Immunoglobulin domain
      cl28434
      Location:805 → 891
      I-set; Immunoglobulin I-set domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A7LCJ3.1 GenPept UniProtKB/Swiss-Prot:A7LCJ3

    Gene LinkOut

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