RLN2 relaxin 2 [Sus scrofa (pig)] - Gene

Summary

Gene symbol: RLN2
Gene description: relaxin 2
See related: Ensembl:ENSSSCG00000005216
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: RLN
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: chromosome: 1

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	1	NC_010443.5 (216763546..216769802)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	1	NC_010443.4 (242497113..242503501)

Chromosome 1 - NC_010443.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Relaxin serves as a model for understanding lactocrine signals that support development of neonatal tissues.
Title: Milk-borne relaxin and reproductive system development.
Swine relaxin provides protection against ischemia-reperfusion-induced renal injury in rats by reducing apoptosis and inflammation.
Title: Relaxin protects against renal ischemia-reperfusion injury.
Establishment of the neonatal porcine uterine developmental program requires maternal lactocrine support via relaxin.
Title: Milk-borne lactocrine-acting factors affect gene expression patterns in the developing neonatal porcine uterus.
Results support the lactocrine hypothesis by defining the nature and a potential source for bioactive proRLX in porcine colostrum/milk.
Title: Characterization and biological activity of relaxin in porcine milk.
Relaxin was detected in denuded oocytes, cumulus cells, mature boar spermatozoa, zygotes, and embryos (cleaved and blastocysts).
Title: Examination of relaxin and its receptors expression in pig gametes and embryos.
Exogenous relaxin influences its own receptors expression, improves oocyte nuclear maturation. Its beneficial effect on total cell number of blastocysts appears to be through a Bcl2-like1/Bax-independent mechanism.
Title: In vitro effects of relaxin on gene expression in porcine cumulus-oocyte complexes and developing embryos.
This study provides evidence for expression of RLN-RXFP1 ligand-receptor system in the boar testis, suggesting that the testes act as a source and possible target tissue of RLN.
Title: Evidence for expression of relaxin hormone-receptor system in the boar testis.
Changes of relaxin mRNA are correlated with changes of the hormone in the CL during pregnancy, suggesting that the relaxin level is determined by the amount of mRNA available for translation.
Title: Expression and cellular pattern of relaxin mRNA in porcine corpora lutea during pregnancy.
Relaxin-producing C2C12 myoblasts displayed greater efficacy to engraft the post-ischaemic scar and to induce extracellular matrix re-modelling and angiogenesis as compared with the control cells
Title: Paracrine effects of transplanted myoblasts and relaxin on post-infarction heart remodelling.
role on neonatal porcine uterine growth and development
Title: Effects of relaxin on neonatal porcine uterine growth and development.

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General gene information

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Markers

RLN (e-PCR), detects polymorphism
- UniSTS:252354

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: prorelaxin

Names: preprorelaxin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213872.1 → NP_999037.1 prorelaxin precursor

See identical proteins and their annotated locations for NP_999037.1

Status: PROVISIONAL

Source sequence(s)

K01088

UniProtKB/Swiss-Prot

P01348

UniProtKB/TrEMBL

A0A4X1W973

Related

ENSSSCP00000005607.3, ENSSSCT00000005749.4

Conserved Domains (1) summary

cd04365
Location:30 → 182

IlGF_relaxin_like; IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), ...

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

NC_010443.5 Reference Sscrofa11.1 Primary Assembly

Range

216763546..216769802

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021082276.1 → XP_020937935.1 prorelaxin isoform X1

Conserved Domains (1) summary

cd04365
Location:77 → 111

IlGF_relaxin_like; IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), ...