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    Ugt1a9 UDP glucuronosyltransferase family 1 member A9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 396552, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Ugt1a9provided by RGD
    Official Full Name
    UDP glucuronosyltransferase family 1 member A9provided by RGD
    Primary source
    RGD:1549771
    See related
    EnsemblRapid:ENSRNOG00000018740 AllianceGenome:RGD:1549771
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ugt1a10; Ugt1a11
    Summary
    Predicted to enable several functions, including glucuronosyltransferase activity; protein dimerization activity; and retinoic acid binding activity. Predicted to be involved in cellular glucuronidation; flavone metabolic process; and negative regulation of small molecule metabolic process. Predicted to be located in endoplasmic reticulum. Orthologous to human UGT1A9 (UDP glucuronosyltransferase family 1 member A9). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Liver (RPKM 1919.8), Kidney (RPKM 838.1) and 2 other tissues See more
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    Genomic context

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    See Ugt1a9 in Genome Data Viewer
    Location:
    9q35
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (96144786..96256264)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (88696981..88808465)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (95161157..95302822)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene diacylglycerol kinase, delta Neighboring gene ubiquitin specific peptidase 40 Neighboring gene UDP glycosyltransferase 1 family, polypeptide A9, pseudogene Neighboring gene uncharacterized LOC108351970 Neighboring gene UDP glucuronosyltransferase family 1 member A8 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A7C Neighboring gene UDP glucuronosyltransferase family 1 member A6 Neighboring gene UDP glycosyltransferase 1 family, polypeptide A4, pseudogene Neighboring gene UDP glucuronosyltransferase family 1 member A5 Neighboring gene UDP glycosyltransferase 1 family, polypeptide A3 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A2 Neighboring gene DnaJ heat shock protein family (Hsp40) member B3 Neighboring gene UDP glucuronosyltransferase family 1 member A1 Neighboring gene maestro heat-like repeat family member 2A Neighboring gene Holliday junction recognition protein Neighboring gene peptidylprolyl isomerase D, pseudogene 21 Neighboring gene transient receptor potential cation channel, subfamily M, member 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Differential down-regulation of the UDP-glucuronosyltransferase 1A locus is an early event in human liver and biliary cancer. Strassburg CP, et al. Cancer Res, 1997 Jul 15. PMID 9230212
    2. Cloning and stable expression of a new member of the human liver phenol/bilirubin: UDP-glucuronosyltransferase cDNA family. Wooster R, et al. Biochem J, 1991 Sep 1. PMID 1910331, Free PMC Article
    3. Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity. Girard H, et al. Pharmacogenet Genomics, 2007 Dec. PMID 18004212
    4. Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms. Joseph TB, et al. Mol Pharm, 2007 Nov-Dec. PMID 18052087, Free PMC Article
    5. Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro. Bellemare J, et al. Drug Metab Dispos, 2010 Oct. PMID 20610558

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables glucuronosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glucuronosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables retinoic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cellular glucuronidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in flavone metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in flavonoid glucuronidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cellular glucuronidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic glucuronidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in xenobiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    UDP glycosyltransferase 1 family, polypeptide A10
    Names
    UDP glucuronosyltransferase 1 family, polypeptide A9
    UDP glycosyltransferase 1 family polypeptide A10
    UDP glycosyltransferase 1 family polypeptide A11
    NP_958828.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201425.2 → NP_958828.1  UDP glycosyltransferase 1 family, polypeptide A10 precursor

      See identical proteins and their annotated locations for NP_958828.1

      Status: VALIDATED

      Source sequence(s)
      AC120922, AY435129
      UniProtKB/TrEMBL
      Q6T5F3
      Related
      ENSRNOP00000025045.5, ENSRNOT00000025045.8
      Conserved Domains (2) summary
      PHA03392
      Location:237 → 504
      egt; ecdysteroid UDP-glucosyltransferase; Provisional
      pfam00201
      Location:26 → 521
      UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      96144786..96256264
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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