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    VLDLR very low density lipoprotein receptor [ Gallus gallus (chicken) ]

    Gene ID: 396154, updated on 17-Aug-2024

    Summary

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    Symbol
    VLDLRprovided by CGNC
    Full Name
    very low density lipoprotein receptorprovided by CGNC
    Primary source
    CGNC:7730
    See related
    Ensembl:ENSGALG00010011837
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    LR8; VLDL; VTGR
    Orthologs
    human mouse all
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    Genomic context

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    See VLDLR in Genome Data Viewer
    Location:
    chromosome: Z
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) Z NC_052572.1 (27059520..27074222)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) Z NC_059536.1 (27059520..27074222)

    Chromosome Z - NC_052572.1Genomic Context describing neighboring genes Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 Neighboring gene uncharacterized LOC107052277 Neighboring gene potassium voltage-gated channel modifier subfamily V member 2 Neighboring gene pumilio RNA binding family member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chicken oocyte growth is mediated by an eight ligand binding repeat member of the LDL receptor family. Bujo H, et al. EMBO J, 1994 Nov 1. PMID 7957081, Free PMC Article
    2. The receptor for yolk lipoprotein deposition in the chicken oocyte. Barber DL, et al. J Biol Chem, 1991 Oct 5. PMID 1655760
    3. Pituitary progesterone receptor expression and plasma gonadotrophin concentrations in the reproductively dysfunctional mutant restricted ovulator chicken. Ocón-Grove OM, et al. Domest Anim Endocrinol, 2007 Apr. PMID 16677794
    4. Receptor-mediated transport and deposition of complement component C3 into developing chicken oocytes. Recheis B, et al. Cell Mol Life Sci, 2005 Aug. PMID 16041564, Free PMC Article
    5. The low density lipoprotein receptor gene family. Differential expression of two alpha2-macroglobulin receptors in the brain. Stockinger W, et al. J Biol Chem, 1998 Nov 27. PMID 9822699

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LR8 binds, internalizes, and deposits the major yolk components in the ratio of their relative abundance in the accessible pool.
      Title: Receptor-mediated transport and deposition of complement component C3 into developing chicken oocytes.
    2. VLDLR transcripts are expressed in the tendon blastemas. Reelin inhibits tenogenic differentiation through VLDLR.
      Title: Reelin/DAB-1 signaling in the embryonic limb regulates the chondrogenic differentiation of digit mesodermal progenitors.
    3. elevated circulating estrogen and/or decreased progesterone levels may have contributed to the upregulation of progesterone receptor mRNA and isoforms A and B in the pituitary gland of restricted ovulator hen, which have a point mutation in VLDLR.
      Title: Pituitary progesterone receptor expression and plasma gonadotrophin concentrations in the reproductively dysfunctional mutant restricted ovulator chicken.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    very low-density lipoprotein receptor
    Names
    VLDL receptor
    VLDL-R
    VTG receptor
    very low density lipoprotein (VLDL)/vitellogenin receptor
    vitellogenin receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205229.2 → NP_990560.1  very low-density lipoprotein receptor precursor

      See identical proteins and their annotated locations for NP_990560.1

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000089
      UniProtKB/Swiss-Prot
      P98165
      Related
      ENSGALP00010016204.1, ENSGALT00010028290.1
      Conserved Domains (7) summary
      smart00192
      Location:210 → 242
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:525 → 567
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:414 → 444
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:51 → 85
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:255 → 291
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:588 → 628
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:378 → 412
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      27059520..27074222
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015280076.4 → XP_015135562.1  very low-density lipoprotein receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0Y6D2
      Related
      ENSGALP00010016210.1, ENSGALT00010028303.1
      Conserved Domains (7) summary
      smart00192
      Location:210 → 242
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:525 → 567
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:414 → 444
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:51 → 85
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:255 → 291
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:588 → 628
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:378 → 412
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_059536.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      27059520..27074222
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046934846.1 → XP_046790802.1  very low-density lipoprotein receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0Y6D2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P98165.1 GenPept UniProtKB/Swiss-Prot:P98165

    Gene LinkOut

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