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    Cers5 ceramide synthase 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366984, updated on 10-Oct-2024

    Summary

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    Official Symbol
    Cers5provided by RGD
    Official Full Name
    ceramide synthase 5provided by RGD
    Primary source
    RGD:1311597
    See related
    EnsemblRapid:ENSRNOG00000052990 AllianceGenome:RGD:1311597
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lass5
    Summary
    Predicted to enable sphingosine N-acyltransferase activity. Predicted to be involved in ceramide biosynthetic process. Predicted to act upstream of or within sphingolipid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane and nucleus. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human CERS5 (ceramide synthase 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 126.3), Thymus (RPKM 90.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cers5 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (132738834..132776920, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (130859993..130897979, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (141386391..141424375, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene glycerol-3-phosphate dehydrogenase 1 Neighboring gene cytochrome c oxidase assembly factor COX14 Neighboring gene uncharacterized LOC134479573 Neighboring gene LIM domain and actin binding 1 Neighboring gene uncharacterized LOC134479574

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Developmentally regulated ceramide synthase 6 increases mitochondrial Ca2+ loading capacity and promotes apoptosis. Novgorodov SA, et al. J Biol Chem, 2011 Feb 11. PMID 21148554, Free PMC Article
    2. LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor. Lahiri S, et al. J Biol Chem, 2005 Oct 7. PMID 16100120
    3. A new functional motif in Hox domain-containing ceramide synthases: identification of a novel region flanking the Hox and TLC domains essential for activity. Mesika A, et al. J Biol Chem, 2007 Sep 14. PMID 17609214
    4. Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity. Spassieva S, et al. J Biol Chem, 2006 Nov 10. PMID 16951403
    5. Eleven residues determine the acyl chain specificity of ceramide synthases. Tidhar R, et al. J Biol Chem, 2018 Jun 22. PMID 29632068, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sphingosine N-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sphingosine N-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ceramide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oligodendrocyte development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within sphingolipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ceramide synthase 5
    Names
    LAG1 homolog, ceramide synthase 5
    LAG1 longevity assurance homolog 5
    longevity assurance homolog 5
    NP_001102463.1
    XP_006257436.1
    XP_006257437.1
    XP_063120139.1
    XP_063120140.1
    XP_063120141.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108993.1 → NP_001102463.1  ceramide synthase 5

      Status: PROVISIONAL

      Source sequence(s)
      CH474035
      UniProtKB/TrEMBL
      A0A8I6AV69, A6KCH5, D4AA91
      Related
      ENSRNOP00000074498.1, ENSRNOT00000084292.3
      Conserved Domains (2) summary
      cd00086
      Location:91 → 136
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam03798
      Location:140 → 333
      TRAM_LAG1_CLN8; TLC domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      132738834..132776920 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006257374.5 → XP_006257436.1  ceramide synthase 5 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AV69, B2RYI9
      Related
      ENSRNOP00000070455.3, ENSRNOT00000080109.3
      Conserved Domains (2) summary
      smart00724
      Location:139 → 339
      TLC; TRAM, LAG1 and CLN8 homology domains
      cd00086
      Location:91 → 136
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    2. XM_063264069.1 → XP_063120139.1  ceramide synthase 5 isoform X3

    3. XM_006257375.4 → XP_006257437.1  ceramide synthase 5 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JXZ1
      Conserved Domains (1) summary
      pfam03798
      Location:103 → 270
      TRAM_LAG1_CLN8; TLC domain

    4. XM_063264071.1 → XP_063120141.1  ceramide synthase 5 isoform X5

    5. XM_063264070.1 → XP_063120140.1  ceramide synthase 5 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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