HA hemagglutinin [Influenza A virus (A/goose/Guangdong/1/1996(H5N1))] - Gene

Summary

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Gene symbol: HA
Gene description: hemagglutinin
Locus tag: FLUAVH5N1_s4gp1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Influenza A virus (A/goose/Guangdong/1/1996(H5N1)) (strain: A/goose/Guangdong/1/1996, serotype: H5N1)
Lineage: Viruses; ssRNA viruses; ssRNA negative-strand viruses; Orthomyxoviridae; Influenzavirus A
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Genomic context

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Location:: segment: 4

Sequence:: NC_007362.1 (22..1728)

NC_007362.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_007362.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Amino acid substitutions in the H5N1 avian influenza haemagglutinin alter pH of fusion and receptor binding to promote a highly pathogenic phenotype in chickens.
Title: Amino acid substitutions in the H5N1 avian influenza haemagglutinin alter pH of fusion and receptor binding to promote a highly pathogenic phenotype in chickens.
The results indicate that relatively high pH optimum of fusion of the hemagglutinin of zoonotic H5N1 and H7N9 influenza viruses allows them to overcome antiviral effects of inefficient endosomal acidification and IFITM3 in human endothelial cells.
Title: HA-Dependent Tropism of H5N1 and H7N9 Influenza Viruses to Human Endothelial Cells Is Determined by Reduced Stability of the HA, Which Allows the Virus To Cope with Inefficient Endosomal Acidification and Constitutively Expressed IFITM3.
Positions 380-461 and 483-565 of HA were novel antigenic epitopes in mouse and chicken.
Title: Characterisation of the antigenic epitopes in the subunit 2 haemagglutinin of avian influenza virus H5N1.
a single nucleotide substitution, resulting in a change from Gly to Asp at position 225 (G225D), completely switches HA specificity to human-type (NeuAcalpha2-6Gal) receptors.
Title: A single mutation in Taiwanese H6N1 influenza hemagglutinin switches binding to human-type receptors.
results showed that a variety of HA variants emerged during single-virus infections of human airway cells, with variant HA properties selected for fitness for human cell infection.
Title: Characterization of H5N1 Influenza Virus Quasispecies with Adaptive Hemagglutinin Mutations from Single-Virus Infections of Human Airway Cells.
Data suggest that expansion of the vaccine hemagglutinin (HA) subunit 1 (HA1) 3D model database will improve international emergency responses to avian influenza virus (AIV).
Title: Visualization of Alternative Functional Configurations of Influenza Virus Hemagglutinin Facilitates Rapid Selection of Complementing Vaccines in Emergency Situations.
Glycosylation of the HA of avian influenza H5N1 modulates virus replication, virulence and chicken-to-chicken transmission.
Title: Progressive glycosylation of the haemagglutinin of avian influenza H5N1 modulates virus replication, virulence and chicken-to-chicken transmission without significant impact on antigenic drift.
Addition of N-glycosylation sites on the globular head of the H5 hemagglutinin induces the escape of immunity.
Title: Addition of N-glycosylation sites on the globular head of the H5 hemagglutinin induces the escape of highly pathogenic avian influenza A H5N1 viruses from vaccine-induced immunity.
K193E and G225E mutations of HA synergistically attenuated H5N1 virus without enhancing the receptor-binding avidity.
Title: H5N1 influenza A virus with K193E and G225E double mutations in haemagglutinin is attenuated and immunogenic in mice.
The influenza hemagglutinin fusion domain is an amphipathic helical hairpin that functions by inducing membrane curvature.
Title: The influenza hemagglutinin fusion domain is an amphipathic helical hairpin that functions by inducing membrane curvature.

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General gene information

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Homology

Orthologs from OrthoDB

General protein information

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Preferred Names: hemagglutinin

Names: HA1; HA2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_007362.1 Reference assembly

Range

22..1728

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

YP_308669.1 hemagglutinin [Influenza A virus (A/goose/Guangdong/1/1996(H5N1))]

See identical proteins and their annotated locations for YP_308669.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

Q9Q0U6, Q9WNX2

UniProtKB/TrEMBL

Q98XR1

Conserved Domains (1) summary

pfam00509
Location:19 → 568

Hemagglutinin; Haemagglutinin
YP_529486.1 HA1

UniProtKB/TrEMBL

Q9WA96
YP_529487.1 HA2

UniProtKB/TrEMBL

C6Y5D9