Nanos2 nanos C2HC-type zinc finger 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nanos2provided by RGD
Official Full Name: nanos C2HC-type zinc finger 2provided by RGD
Primary source: RGD:1562436
See related: EnsemblRapid:ENSRNOG00000074804 AllianceGenome:RGD:1562436
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1562436
Summary: Predicted to enable enzyme activator activity and mRNA binding activity. Predicted to be involved in several processes, including germ-line stem cell population maintenance; negative regulation of gene expression; and negative regulation of meiotic nuclear division. Predicted to act upstream of or within spermatogenesis. Predicted to be located in P-body and nucleus. Predicted to be active in perinuclear region of cytoplasm. Orthologous to human NANOS2 (nanos C2HC-type zinc finger 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (87763716..87765176)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (78635668..78637128)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (79894450..79895910)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Stage-specific expression of Nanos2 occurred on different embryonic developmental days, while during the postnatal period Nanos2 expression is restricted to undifferentiated spermatogonia and spermatogonial stem cells .
Title: Expression and intracellular localization of Nanos2-homologue protein in primordial germ cells and spermatogonial stem cells.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme activator activity	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in germ-line stem cell population maintenance	ISO Inferred from Sequence Orthology more info
involved_in mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in mRNA destabilization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of meiotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in oogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in P-body	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nanos homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.