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    Slamf7 SLAM family member 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364049, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Slamf7provided by RGD
    Official Full Name
    SLAM family member 7provided by RGD
    Primary source
    RGD:1560190
    See related
    EnsemblRapid:ENSRNOG00000023209 AllianceGenome:RGD:1560190
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560190
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in T cell activation and immune response. Predicted to act upstream of or within regulation of natural killer cell activation. Predicted to be located in endoplasmic reticulum and plasma membrane. Predicted to be active in external side of plasma membrane. Orthologous to human SLAMF7 (SLAM family member 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 228.3), Thymus (RPKM 177.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slamf7 in Genome Data Viewer
    Location:
    13q24
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (86668060..86688222, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (84135656..84154528, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (90056726..90075159, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene lymphocyte antigen 9 Neighboring gene uncharacterized LOC102549964 Neighboring gene uncharacterized LOC103692286 Neighboring gene Cd48 molecule

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cutting edge: NTB-A activates NK cells via homophilic interaction. Flaig RM, et al. J Immunol, 2004 Jun 1. PMID 15153464
    2. Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function. Cruz-Munoz ME, et al. Nat Immunol, 2009 Mar. PMID 19151721
    3. Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells. Dong Z, et al. Nat Immunol, 2009 Sep. PMID 19648922
    4. A secreted protein microarray platform for extracellular protein interaction discovery. Ramani SR, et al. Anal Biochem, 2012 Jan 15. PMID 21982860
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of natural killer cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SLAM family member 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001412827.1 → NP_001399756.1  SLAM family member 7 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A0G2K5F6
      Related
      ENSRNOP00000073407.1, ENSRNOT00000088884.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      86668060..86688222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090954.2 → XP_038946882.1  SLAM family member 7 isoform X1

      UniProtKB/TrEMBL
      A6JG06, D4ABU3
      Related
      ENSRNOP00000038176.5, ENSRNOT00000038006.7
      Conserved Domains (2) summary
      cd00096
      Location:27 → 32
      Ig; Ig strand A [structural motif]
      cl11960
      Location:27 → 123
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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