Otud5 OTU deubiquitinase 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Otud5provided by RGD
Official Full Name: OTU deubiquitinase 5provided by RGD
Primary source: RGD:1563027
See related: EnsemblRapid:ENSRNOG00000008764 AllianceGenome:RGD:1563027
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable K48-linked deubiquitinase activity; K63-linked deubiquitinase activity; and cysteine-type deubiquitinase activity. Predicted to be involved in several processes, including negative regulation of canonical Wnt signaling pathway; positive regulation of TOR signaling; and protein deubiquitination. Predicted to act upstream of or within several processes, including alpha-beta T cell differentiation; negative regulation of interleukin-17 production; and regulation of T-helper 17 type immune response. Predicted to be located in nucleus. Orthologous to human OTUD5 (OTU deubiquitinase 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 267.8), Spleen (RPKM 221.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (17296750..17331257, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (14626173..14659331, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (15471212..15504372, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Slc25a39 (e-PCR), detects polymorphism
- UniSTS:547326

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables K48-linked deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables K48-linked deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables K48-linked deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables K63-linked deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables K63-linked deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables K63-linked deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables K63-linked deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within CD8-positive, alpha-beta T cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T-helper 17 cell lineage commitment	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of interleukin-17 production	ISO Inferred from Sequence Orthology more info
involved_in neural crest cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in neural crest cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in neural crest cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of TORC1 signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TORC2 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of TORC2 signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of TORC2 signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked deubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein K48-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K63-linked deubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein K63-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of T-helper 17 type immune response	ISO Inferred from Sequence Orthology more info
involved_in regulation of immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: OTU domain-containing protein 5

Names: DUBA; OTU domain containing 5; deubiquinating enzyme A; deubiquitinating enzyme A

NP_001032585.1

EC 3.4.19.12

NP_001401659.1

EC 3.4.19.12

XP_006256799.1

EC 3.4.19.12

XP_006256802.1

EC 3.4.19.12

XP_006256803.1

EC 3.4.19.12

XP_063136188.1

EC 3.4.19.12

XP_063136189.1

EC 3.4.19.12

XP_063136190.1

EC 3.4.19.12

XP_063136191.1

EC 3.4.19.12

XP_063136192.1

EC 3.4.19.12

XP_063136193.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037496.1 → NP_001032585.1 OTU domain-containing protein 5 isoform 2

See identical proteins and their annotated locations for NP_001032585.1

Status: PROVISIONAL

Source sequence(s)

BC110054

UniProtKB/TrEMBL

A6KP74

Conserved Domains (1) summary

cl19932
Location:178 → 287

OTU; OTU-like cysteine protease
NM_001414730.1 → NP_001401659.1 OTU domain-containing protein 5 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

Q2YDU3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

17296750..17331257 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006256737.5 → XP_006256799.1 OTU domain-containing protein 5 isoform X1

UniProtKB/TrEMBL

A0A8I6AAB2, A6KP75

Related

ENSRNOP00000090218.1, ENSRNOT00000112857.2

Conserved Domains (1) summary

cl19932
Location:294 → 403

OTU; OTU-like cysteine protease
XM_063280120.1 → XP_063136190.1 OTU domain-containing protein 5 isoform X4
XM_006256741.5 → XP_006256803.1 OTU domain-containing protein 5 isoform X6

UniProtKB/TrEMBL

A0A0H2UHD0, A6KP74

Related

ENSRNOP00000006233.6, ENSRNOT00000006233.9

Conserved Domains (1) summary

cl19932
Location:251 → 360

OTU; OTU-like cysteine protease
XM_006256740.5 → XP_006256802.1 OTU domain-containing protein 5 isoform X5

UniProtKB/TrEMBL

A6KP74

Conserved Domains (1) summary

cl19932
Location:251 → 360

OTU; OTU-like cysteine protease
XM_063280121.1 → XP_063136191.1 OTU domain-containing protein 5 isoform X7
XM_063280119.1 → XP_063136189.1 OTU domain-containing protein 5 isoform X3
XM_063280118.1 → XP_063136188.1 OTU domain-containing protein 5 isoform X2
XM_063280122.1 → XP_063136192.1 OTU domain-containing protein 5 isoform X8
XM_063280123.1 → XP_063136193.1 OTU domain-containing protein 5 isoform X9