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    Ube2f ubiquitin-conjugating enzyme E2F (putative) [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363284, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ube2fprovided by RGD
    Official Full Name
    ubiquitin-conjugating enzyme E2F (putative)provided by RGD
    Primary source
    RGD:1307608
    See related
    EnsemblRapid:ENSRNOG00000019953 AllianceGenome:RGD:1307608
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307608
    Summary
    Predicted to enable NEDD8 conjugating enzyme activity. Predicted to be involved in protein neddylation. Predicted to be active in cytosol and nucleus. Orthologous to human UBE2F (ubiquitin conjugating enzyme E2 F (putative)). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 198.3), Kidney (RPKM 153.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ube2f in Genome Data Viewer
    Location:
    9q36
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (99293506..99328690)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (91845975..91881145)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (98394112..98428684)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene receptor activity modifying protein 1 Neighboring gene pyruvate kinase M1/2, pseudogene 10 Neighboring gene selenocysteine lyase Neighboring gene espin-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. Huang DT, et al. Mol Cell, 2009 Feb 27. PMID 19250909, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105540

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NEDD8 conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NEDD8 conjugating enzyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables NEDD8 ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NEDD8 transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NEDD8 transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein neddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein neddylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein neddylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein neddylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NEDD8-conjugating enzyme UBE2F
    Names
    NEDD8 carrier protein UBE2F
    NEDD8 protein ligase UBE2F
    RING-type E3 NEDD8 transferase UBE2F
    ubiquitin-conjugating enzyme E2 F
    NP_001008382.1
    NP_001386083.1
    NP_001386084.1
    NP_001386085.1
    NP_001386086.1
    NP_001386087.1
    NP_001386088.1
    NP_001386101.1
    XP_006245485.1
    XP_017452028.1
    XP_038939848.1
    XP_063123523.1
    XP_063123524.1
    XP_063123525.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008381.2 → NP_001008382.1  NEDD8-conjugating enzyme UBE2F isoform 3

      See identical proteins and their annotated locations for NP_001008382.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6ALE6
      Related
      ENSRNOP00000040354.2, ENSRNOT00000042082.6
      Conserved Domains (2) summary
      smart00212
      Location:49 → 162
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
      COG5078
      Location:30 → 162
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

    2. NM_001399154.1 → NP_001386083.1  NEDD8-conjugating enzyme UBE2F isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q5U203
      UniProtKB/TrEMBL
      A6JQQ2
      Conserved Domains (1) summary
      cl00154
      Location:30 → 184
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    3. NM_001399155.1 → NP_001386084.1  NEDD8-conjugating enzyme UBE2F isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q5U203
      UniProtKB/TrEMBL
      A6JQQ2
      Related
      ENSRNOP00000099170.1, ENSRNOT00000170276.1
      Conserved Domains (1) summary
      cl00154
      Location:30 → 184
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    4. NM_001399156.1 → NP_001386085.1  NEDD8-conjugating enzyme UBE2F isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q5U203
      UniProtKB/TrEMBL
      A6JQQ2
      Conserved Domains (1) summary
      cl00154
      Location:30 → 184
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    5. NM_001399157.1 → NP_001386086.1  NEDD8-conjugating enzyme UBE2F isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6JQQ3
      Related
      ENSRNOP00000110584.1, ENSRNOT00000137103.1
      Conserved Domains (1) summary
      cl00154
      Location:61 → 174
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    6. NM_001399158.1 → NP_001386087.1  NEDD8-conjugating enzyme UBE2F isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      Conserved Domains (1) summary
      cl00154
      Location:40 → 152
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    7. NM_001399159.1 → NP_001386088.1  NEDD8-conjugating enzyme UBE2F isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      Conserved Domains (1) summary
      cl00154
      Location:40 → 152
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    8. NM_001399172.1 → NP_001386101.1  NEDD8-conjugating enzyme UBE2F isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      99293506..99328690
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267454.1 → XP_063123524.1  NEDD8-conjugating enzyme UBE2F isoform X2

      UniProtKB/TrEMBL
      A6JQQ3

    2. XM_063267455.1 → XP_063123525.1  NEDD8-conjugating enzyme UBE2F isoform X3

    3. XM_017596539.3 → XP_017452028.1  NEDD8-conjugating enzyme UBE2F isoform X1

      UniProtKB/Swiss-Prot
      Q5U203
      UniProtKB/TrEMBL
      A0A8I6ALE6, A6JQQ2
      Conserved Domains (1) summary
      cl00154
      Location:30 → 184
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    4. XM_063267453.1 → XP_063123523.1  NEDD8-conjugating enzyme UBE2F isoform X1

      UniProtKB/Swiss-Prot
      Q5U203
      UniProtKB/TrEMBL
      A6JQQ2

    5. XM_006245423.5 → XP_006245485.1  NEDD8-conjugating enzyme UBE2F isoform X1

      See identical proteins and their annotated locations for XP_006245485.1

      UniProtKB/Swiss-Prot
      Q5U203
      UniProtKB/TrEMBL
      A0A8I6ALE6, A6JQQ2
      Related
      ENSRNOP00000027050.5, ENSRNOT00000027050.9
      Conserved Domains (1) summary
      cl00154
      Location:30 → 184
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    6. XM_039083920.2 → XP_038939848.1  NEDD8-conjugating enzyme UBE2F isoform X1

      UniProtKB/Swiss-Prot
      Q5U203
      UniProtKB/TrEMBL
      A0A8I6ALE6, A6JQQ2
      Conserved Domains (1) summary
      cl00154
      Location:30 → 184
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U203.2 GenPept UniProtKB/Swiss-Prot:Q5U203

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