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    Ppp2r5d protein phosphatase 2, regulatory subunit B', delta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363193, updated on 2-Nov-2024

    Summary

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    Symbol
    Ppp2r5dprovided by RGD
    Full Name
    protein phosphatase 2, regulatory subunit B', deltaprovided by RGD
    Primary source
    RGD:1306666
    See related
    EnsemblRapid:ENSRNOG00000016849 AllianceGenome:RGD:1306666
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphoprotein phosphatase activity and protein phosphatase activator activity. Involved in negative regulation of peptidyl-threonine phosphorylation. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 35. Orthologous to human PPP2R5D (protein phosphatase 2 regulatory subunit B'delta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 151.8), Thymus (RPKM 140.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppp2r5d in Genome Data Viewer
    Location:
    9q12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (21767963..21797997)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (14270364..14300396)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (16580995..16610425)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene canopy FGF signaling regulator 3 Neighboring gene glycine N-methyltransferase Neighboring gene peroxisomal biogenesis factor 6 Neighboring gene kelch domain containing 3 Neighboring gene male-enhanced antigen 1 Neighboring gene ribosomal RNA processing 36

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. β-Adrenergic regulation of cardiac type 2A protein phosphatase through phosphorylation of regulatory subunit B56δ at S573. Ranieri A, et al. J Mol Cell Cardiol, 2018 Feb. PMID 29294329, Free PMC Article
    2. Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56delta subunit. Ahn JH, et al. Proc Natl Acad Sci U S A, 2007 Feb 20. PMID 17301223, Free PMC Article
    3. Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta. Louis JV, et al. Proc Natl Acad Sci U S A, 2011 Apr 26. PMID 21482799, Free PMC Article
    4. A phosphatase cascade by which rewarding stimuli control nucleosomal response. Stipanovich A, et al. Nature, 2008 Jun 12. PMID 18496528, Free PMC Article
    5. Bod1 regulates protein phosphatase 2A at mitotic kinetochores. Porter IM, et al. Nat Commun, 2013. PMID 24157919, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427099.1 → NP_001414028.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      Related
      ENSRNOP00000022862.7, ENSRNOT00000022862.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      21767963..21797997
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267359.1 → XP_063123429.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X2

      UniProtKB/TrEMBL
      A0A8I6A6K6

    2. XM_017596731.3 → XP_017452220.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1

      UniProtKB/TrEMBL
      Q499R1
      Conserved Domains (2) summary
      PLN00122
      Location:488 → 588
      PLN00122; serine/threonine protein phosphatase 2A; Provisional
      pfam01603
      Location:180 → 583
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    3. XM_001062510.8 → XP_001062510.4  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X2

      See identical proteins and their annotated locations for XP_001062510.4

      UniProtKB/TrEMBL
      A0A8I6A6K6, Q499R1
      Related
      ENSRNOP00000086619.1, ENSRNOT00000108773.2
      Conserved Domains (2) summary
      PLN00122
      Location:487 → 587
      PLN00122; serine/threonine protein phosphatase 2A; Provisional
      pfam01603
      Location:179 → 582
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    4. XM_006244570.5 → XP_006244632.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1

      See identical proteins and their annotated locations for XP_006244632.1

      UniProtKB/TrEMBL
      Q499R1
      Conserved Domains (2) summary
      PLN00122
      Location:488 → 588
      PLN00122; serine/threonine protein phosphatase 2A; Provisional
      pfam01603
      Location:180 → 583
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)
    Nucleotide Protein Strain
    Heading Accession and Version

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