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    Skic8 SKI8 subunit of superkiller complex [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363064, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Skic8provided by RGD
    Official Full Name
    SKI8 subunit of superkiller complexprovided by RGD
    Primary source
    RGD:1308228
    See related
    EnsemblRapid:ENSRNOG00000012803 AllianceGenome:RGD:1308228
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ski8; Wdr61; RGD1308228
    Summary
    Predicted to be involved in RNA metabolic process; negative regulation of myeloid cell differentiation; and rescue of stalled ribosome. Predicted to be located in cytosol; euchromatin; and nucleoplasm. Predicted to be part of Cdc73/Paf1 complex and Ski complex. Orthologous to human SKIC8 (SKI8 subunit of superkiller complex). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 189.9), Lung (RPKM 148.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Skic8 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (63999669..64016959, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (55103542..55120837, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (59296339..59313663, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene acyl-CoA synthetase bubblegum family member 1 Neighboring gene DnaJ heat shock protein family (Hsp40) member A4 Neighboring gene cellular retinoic acid binding protein 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4, pseudogene 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Paf1 complex: platform or player in RNA polymerase II transcription? Jaehning JA. Biochim Biophys Acta, 2010 May-Jun. PMID 20060942, Free PMC Article
    2. Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a. Strikoudis A, et al. Nat Cell Biol, 2016 Nov. PMID 27749823, Free PMC Article
    3. The human PAF complex coordinates transcription with events downstream of RNA synthesis. Zhu B, et al. Genes Dev, 2005 Jul 15. PMID 16024656, Free PMC Article
    4. The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis. Muntean AG, et al. Cancer Cell, 2010 Jun 15. PMID 20541477, Free PMC Article
    5. The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS. Kim J, et al. Cell, 2010 Feb 19. PMID 20178742, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC116220

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of myeloid cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of myeloid cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of myeloid cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in rescue of stalled ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rescue of stalled ribosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription elongation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription elongation by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Cdc73/Paf1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cdc73/Paf1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Cdc73/Paf1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cdc73/Paf1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of Ski complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Ski complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Ski complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in euchromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in euchromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in euchromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    superkiller complex protein 8
    Names
    SKI8 subunit of superkiller complex protein
    WD repeat domain 61
    WD repeat-containing protein 61

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025743.1 → NP_001020914.1  superkiller complex protein 8

      See identical proteins and their annotated locations for NP_001020914.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098059
      UniProtKB/Swiss-Prot
      Q4V7A0
      UniProtKB/TrEMBL
      A6J4M6
      Related
      ENSRNOP00000104942.1, ENSRNOT00000172018.1
      Conserved Domains (2) summary
      cd00200
      Location:13 → 302
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:110 → 146
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      63999669..64016959 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243085.5 → XP_006243147.1  superkiller complex protein 8 isoform X1

      See identical proteins and their annotated locations for XP_006243147.1

      UniProtKB/Swiss-Prot
      Q4V7A0
      UniProtKB/TrEMBL
      A6J4M6
      Conserved Domains (2) summary
      cd00200
      Location:13 → 302
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:110 → 146
      7WD40; WD40 repeat [structural motif]

    2. XM_006243086.4 → XP_006243148.1  superkiller complex protein 8 isoform X1

      See identical proteins and their annotated locations for XP_006243148.1

      UniProtKB/Swiss-Prot
      Q4V7A0
      UniProtKB/TrEMBL
      A6J4M6
      Conserved Domains (2) summary
      cd00200
      Location:13 → 302
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:110 → 146
      7WD40; WD40 repeat [structural motif]

    3. XM_017595735.3 → XP_017451224.1  superkiller complex protein 8 isoform X2

      Conserved Domains (2) summary
      cd00200
      Location:14 → 204
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:12 → 48
      7WD40; WD40 repeat [structural motif]

    4. XM_063265747.1 → XP_063121817.1  superkiller complex protein 8 isoform X2

    5. XM_039081731.2 → XP_038937659.1  superkiller complex protein 8 isoform X1

      UniProtKB/Swiss-Prot
      Q4V7A0
      UniProtKB/TrEMBL
      A6J4M6
      Conserved Domains (2) summary
      cd00200
      Location:13 → 302
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:110 → 146
      7WD40; WD40 repeat [structural motif]

    6. XM_006243087.4 → XP_006243149.1  superkiller complex protein 8 isoform X2

      Conserved Domains (2) summary
      cd00200
      Location:14 → 204
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:12 → 48
      7WD40; WD40 repeat [structural motif]

    7. XM_063265748.1 → XP_063121818.1  superkiller complex protein 8 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V7A0.1 GenPept UniProtKB/Swiss-Prot:Q4V7A0

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