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    Rrm2 ribonucleotide reductase regulatory subunit M2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362720, updated on 2-Nov-2024

    Summary

    Official Symbol
    Rrm2provided by RGD
    Official Full Name
    ribonucleotide reductase regulatory subunit M2provided by RGD
    Primary source
    RGD:1598310
    See related
    EnsemblRapid:ENSRNOG00000054286 AllianceGenome:RGD:1598310
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ferric iron binding activity; protein homodimerization activity; and ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in positive regulation of cell population proliferation and pyrimidine nucleobase metabolic process. Located in nuclear envelope. Used to study endometrial adenocarcinoma. Biomarker of urinary bladder cancer. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human RRM2 (ribonucleotide reductase regulatory subunit M2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 533.8), Spleen (RPKM 381.5) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Rrm2 in Genome Data Viewer
    Location:
    6q16
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (47044755..47075370)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (41339858..41346774)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (43884627..43890818)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene grainyhead-like transcription factor 1 Neighboring gene KLF transcription factor 11 Neighboring gene cystin 1 Neighboring gene uncharacterized LOC120093240 Neighboring gene uncharacterized LOC134479350

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC116120

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in 2'-deoxyribonucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in 2'-deoxyribonucleotide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in blastocyst development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of blastocyst development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in deoxyribonucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in deoxyribonucleotide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in deoxyribonucleotide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within deoxyribonucleotide metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein heterotetramerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein heterotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pyrimidine nucleobase metabolic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in ribonucleoside diphosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ribonucleoside diphosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ribonucleoside-diphosphate reductase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of ribonucleoside-diphosphate reductase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ribonucleoside-diphosphate reductase subunit M2
    Names
    Ribonucleotide reductase 2
    ribonucleotide reductase M2 polypeptide
    ribonucleotide reductase small chain
    ribonucleotide reductase small subunit
    NP_001020911.1
    XP_038968417.1
    XP_063118143.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025740.3NP_001020911.1  ribonucleoside-diphosphate reductase subunit M2

      See identical proteins and their annotated locations for NP_001020911.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      Q4KLN6
      UniProtKB/TrEMBL
      A6HAY1
      Related
      ENSRNOP00000073334.3, ENSRNOT00000091551.3
      Conserved Domains (1) summary
      PLN02492
      Location:71390
      PLN02492; ribonucleoside-diphosphate reductase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      47044755..47075370
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262073.1XP_063118143.1  ribonucleoside-diphosphate reductase subunit M2 isoform X2

      UniProtKB/Swiss-Prot
      Q4KLN6
      UniProtKB/TrEMBL
      A6HAY1
    2. XM_039112489.2XP_038968417.1  ribonucleoside-diphosphate reductase subunit M2 isoform X1

      UniProtKB/TrEMBL
      A0A8L2R734
      Conserved Domains (1) summary
      PLN02492
      Location:79398
      PLN02492; ribonucleoside-diphosphate reductase