Agbl5 AGBL carboxypeptidase 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Agbl5provided by RGD
Official Full Name: AGBL carboxypeptidase 5provided by RGD
Primary source: RGD:1598311
See related: EnsemblRapid:ENSRNOG00000008612 AllianceGenome:RGD:1598311
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable metallocarboxypeptidase activity and tubulin binding activity. Predicted to be involved in defense response to virus and protein deglutamylation. Predicted to be located in several cellular components, including intercellular bridge; midbody; and mitotic spindle. Predicted to be active in cytoplasm and microtubule cytoskeleton. Human ortholog(s) of this gene implicated in retinitis pigmentosa 75. Orthologous to human AGBL5 (AGBL carboxypeptidase 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 238.6), Kidney (RPKM 50.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q14

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (31192281..31213494, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (25472333..25492173, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (26837299..26857234, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

AA850556 (e-PCR)
- UniSTS:250388

BG379037 (e-PCR)
- UniSTS:245543

BF406564 (e-PCR)
- UniSTS:248389

RH138484 (e-PCR)
- UniSTS:220571

MARC_23457-23458:1027109061:1 (e-PCR)
- UniSTS:268705

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metallocarboxypeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallocarboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallocarboxypeptidase activity	ISO Inferred from Sequence Orthology more info
enables metallocarboxypeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables tubulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables tubulin binding	IEA Inferred from Electronic Annotation more info
enables tubulin binding	ISO Inferred from Sequence Orthology more info
enables tubulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in C-terminal protein deglutamylation	IEA Inferred from Electronic Annotation more info
involved_in C-terminal protein deglutamylation	ISO Inferred from Sequence Orthology more info
involved_in C-terminal protein deglutamylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein branching point deglutamylation	IEA Inferred from Electronic Annotation more info
involved_in protein branching point deglutamylation	ISO Inferred from Sequence Orthology more info
involved_in protein branching point deglutamylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein deglutamylation	ISO Inferred from Sequence Orthology more info
involved_in protein deglutamylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein side chain deglutamylation	IEA Inferred from Electronic Annotation more info
involved_in protein side chain deglutamylation	ISO Inferred from Sequence Orthology more info
involved_in protein side chain deglutamylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in intercellular bridge	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
located_in mitotic spindle	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytosolic carboxypeptidase-like protein 5

Names: ATP/GTP binding protein-like 5; protein deglutamylase CCP5

NP_001119844.1

EC 3.4.17.24

XP_038968402.1

EC 3.4.17.24

XP_038968404.1

EC 3.4.17.24

XP_038968405.1

EC 3.4.17.24

XP_063118123.1

EC 3.4.17.24

XP_063118124.1

EC 3.4.17.24

XP_063118125.1

EC 3.4.17.24

XP_063118126.1

EC 3.4.17.24

XP_063118127.1

EC 3.4.17.24

XP_063118129.1

EC 3.4.17.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001126372.1 → NP_001119844.1 cytosolic carboxypeptidase-like protein 5

See identical proteins and their annotated locations for NP_001119844.1

Status: PROVISIONAL

Source sequence(s)

BC166490

UniProtKB/Swiss-Prot

B2GV17

UniProtKB/TrEMBL

A0A8L2Q5F9

Related

ENSRNOP00000011635.6, ENSRNOT00000011635.7

Conserved Domains (1) summary

cd06236
Location:176 → 569

M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

31192281..31213494 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063262053.1 → XP_063118123.1 cytosolic carboxypeptidase-like protein 5 isoform X1
XM_063262056.1 → XP_063118126.1 cytosolic carboxypeptidase-like protein 5 isoform X4
XM_063262055.1 → XP_063118125.1 cytosolic carboxypeptidase-like protein 5 isoform X3
XM_063262054.1 → XP_063118124.1 cytosolic carboxypeptidase-like protein 5 isoform X2
XM_039112477.2 → XP_038968405.1 cytosolic carboxypeptidase-like protein 5 isoform X6

UniProtKB/TrEMBL

A0A8I6GKG2, A6HAB8

Conserved Domains (2) summary

cd06236
Location:183 → 575

M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins

pfam18027
Location:10 → 155

Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain
XM_039112476.2 → XP_038968404.1 cytosolic carboxypeptidase-like protein 5 isoform X6

UniProtKB/TrEMBL

A0A8I6GKG2, A6HAB8

Conserved Domains (2) summary

cd06236
Location:183 → 575

M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins

pfam18027
Location:10 → 155

Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain
XM_039112474.2 → XP_038968402.1 cytosolic carboxypeptidase-like protein 5 isoform X6

UniProtKB/TrEMBL

A0A8I6GKG2, A6HAB8

Related

ENSRNOP00000093808.1, ENSRNOT00000111053.2

Conserved Domains (2) summary

cd06236
Location:183 → 575

M14_AGBL5_like; Peptidase M14-like domain of ATP/GTP binding protein (AGBL)-5 and related proteins

pfam18027
Location:10 → 155

Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain
XM_063262057.1 → XP_063118127.1 cytosolic carboxypeptidase-like protein 5 isoform X5
XM_063262059.1 → XP_063118129.1 cytosolic carboxypeptidase-like protein 5 isoform X7