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    Inpp5b inositol polyphosphate-5-phosphatase B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362590, updated on 2-Nov-2024

    Summary

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    Symbol
    Inpp5bprovided by RGD
    Full Name
    inositol polyphosphate-5-phosphatase Bprovided by RGD
    Primary source
    RGD:1311511
    See related
    EnsemblRapid:ENSRNOG00000048506 AllianceGenome:RGD:1311511
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable inositol-1,4,5-trisphosphate 5-phosphatase activity and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation. Predicted to act upstream of or within several processes, including flagellated sperm motility; in utero embryonic development; and regulation of protein processing. Predicted to be located in early endosome membrane and phagocytic vesicle membrane. Predicted to be active in cytosol; membrane; and neuron projection. Orthologous to human INPP5B (inositol polyphosphate-5-phosphatase B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 205.7), Lung (RPKM 165.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Inpp5b in Genome Data Viewer
    Location:
    5q36
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (142281454..142345993)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (136996766..137061315)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (142731767..142796305)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene four and a half LIM domains 3 Neighboring gene splicing factor 3a, subunit 3 Neighboring gene uncharacterized LOC120102976 Neighboring gene metal-regulatory transcription factor 1 Neighboring gene similar to human chromosome 1 open reading frame 122

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Properties of type II inositol polyphosphate 5-phosphatase. Jefferson AB, et al. J Biol Chem, 1995 Apr 21. PMID 7721860
    2. Disrupted sperm function and fertilin beta processing in mice deficient in the inositol polyphosphate 5-phosphatase Inpp5b. Hellsten E, et al. Dev Biol, 2001 Dec 15. PMID 11784089
    3. Distinct membrane and cytosolic forms of inositol polyphosphate 5-phosphatase II. Efficient membrane localization requires two discrete domains. Matzaris M, et al. J Biol Chem, 1998 Apr 3. PMID 9525932
    4. X-inactivation analysis of embryonic lethality in Ocrl wt/-; Inpp5b-/- mice. Bernard DJ, et al. Mamm Genome, 2010 Apr. PMID 20195868, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables inositol-1,4,5-trisphosphate 5-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol-1,4,5-trisphosphate 5-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in phagocytic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    type II inositol 1,4,5-trisphosphate 5-phosphatase
    Names
    type II inositol 1,4,5-trisphosphate 5-phosphatase-like
    NP_001094225.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100755.1 → NP_001094225.1  type II inositol 1,4,5-trisphosphate 5-phosphatase

      Status: VALIDATED

      Source sequence(s)
      BC098852, CB324491, CB611564, CB748743, JAXUCZ010000005
      UniProtKB/TrEMBL
      F1LP71
      Related
      ENSRNOP00000010885.9, ENSRNOT00000010885.9
      Conserved Domains (3) summary
      cd09093
      Location:268 → 561
      INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
      cd04380
      Location:695 → 915
      RhoGAP_OCRL1; RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate ...
      pfam16776
      Location:6 → 150
      INPP5B_PH; Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      142281454..142345993
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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