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    Bub3 BUB3 mitotic checkpoint protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361662, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Bub3provided by RGD
    Official Full Name
    BUB3 mitotic checkpoint proteinprovided by RGD
    Primary source
    RGD:1306654
    See related
    EnsemblRapid:ENSRNOG00000020643 AllianceGenome:RGD:1306654
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Aa2-050
    Summary
    Predicted to be involved in attachment of spindle microtubules to kinetochore; protein localization to kinetochore; and regulation of chromosome segregation. Predicted to be located in kinetochore and nucleoplasm. Predicted to be part of mitotic checkpoint complex. Orthologous to human BUB3 (BUB3 mitotic checkpoint protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 389.1), Spleen (RPKM 268.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bub3 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (195760532..195771140)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (186330358..186340969)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (203526853..203537459)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene H6 family homeobox 3 Neighboring gene H6 family homeobox 2 Neighboring gene uncharacterized LOC134485182 Neighboring gene uncharacterized LOC120099942

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Bub3 is a spindle assembly checkpoint protein regulating chromosome segregation during mouse oocyte meiosis. Li M, et al. PLoS One, 2009 Nov 2. PMID 19888327, Free PMC Article
    2. The human spindle assembly checkpoint protein Bub3 is required for the establishment of efficient kinetochore-microtubule attachments. Logarinho E, et al. Mol Biol Cell, 2008 Apr. PMID 18199686, Free PMC Article
    3. Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice. Baker DJ, et al. J Cell Biol, 2006 Feb 13. PMID 16476774, Free PMC Article
    4. Increased chromosome instability but not cancer predisposition in haploinsufficient Bub3 mice. Kalitsis P, et al. Genes Chromosomes Cancer, 2005 Sep. PMID 15898111
    5. The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase. Taylor SS, et al. J Cell Biol, 1998 Jul 13. PMID 9660858, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in attachment of spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitotic checkpoint complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitotic checkpoint protein BUB3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001047906.2 → NP_001041371.2  mitotic checkpoint protein BUB3

      See identical proteins and their annotated locations for NP_001041371.2

      Status: VALIDATED

      Source sequence(s)
      BC099199, DY575212
      UniProtKB/TrEMBL
      A0A0G2JU63, Q4FZS2
      Related
      ENSRNOP00000101461.1, ENSRNOT00000158776.1
      Conserved Domains (2) summary
      sd00039
      Location:17 → 54
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:14 → 296
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      195760532..195771140
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083223.2 → XP_038939151.1  mitotic checkpoint protein BUB3 isoform X1

      Conserved Domains (2) summary
      sd00039
      Location:19 → 54
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:3 → 216
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Chemical Information
    Molecular Biology Databases
    Research Materials