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    Rhbdd2 rhomboid domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360793, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rhbdd2provided by RGD
    Official Full Name
    rhomboid domain containing 2provided by RGD
    Primary source
    RGD:1308231
    See related
    EnsemblRapid:ENSRNOG00000001443 AllianceGenome:RGD:1308231
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rhbdl7
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be located in Golgi membrane; nucleoplasm; and perinuclear region of cytoplasm. Orthologous to human RHBDD2 (rhomboid domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 82.2), Kidney (RPKM 66.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rhbdd2 in Genome Data Viewer
    Location:
    12q12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (26680206..26690926, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (21043605..21054305, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (24091132..24102081, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 120A Neighboring gene cytochrome p450 oxidoreductase Neighboring gene C-C motif chemokine ligand 24 Neighboring gene C-C motif chemokine ligand 26

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Dynamics of the rhomboid-like protein RHBDD2 expression in mouse retina and involvement of its human ortholog in retinitis pigmentosa. Ahmedli NB, et al. J Biol Chem, 2013 Apr 5. PMID 23386608, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rhomboid domain-containing protein 2
    Names
    rhomboid, veinlet-like 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191827.1 → NP_001178756.1  rhomboid domain-containing protein 2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      D3ZQG3
      Related
      ENSRNOP00000001962.5, ENSRNOT00000001962.8
      Conserved Domains (1) summary
      pfam01694
      Location:54 → 202
      Rhomboid; Rhomboid family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      26680206..26690926 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249182.5 → XP_006249244.1  rhomboid domain-containing protein 2 isoform X1

      Conserved Domains (1) summary
      pfam03154
      Location:108 → 208
      Atrophin-1; Atrophin-1 family
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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