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    Tada2a transcriptional adaptor 2A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360581, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Tada2aprovided by RGD
    Official Full Name
    transcriptional adaptor 2Aprovided by RGD
    Primary source
    RGD:1309959
    See related
    EnsemblRapid:ENSRNOG00000002757 AllianceGenome:RGD:1309959
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tada2l
    Summary
    Predicted to enable chromatin binding activity and transcription coactivator activity. Predicted to contribute to histone acetyltransferase activity. Predicted to be involved in several processes, including chromatin remodeling; histone H3 acetylation; and positive regulation of histone acetylation. Predicted to act upstream of or within mitotic cell cycle; regulation of protein modification process; and regulation of protein stability. Predicted to be located in mitotic spindle. Predicted to be part of ATAC complex and SAGA complex. Predicted to be active in nucleus. Orthologous to human TADA2A (transcriptional adaptor 2A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 105.5), Brain (RPKM 87.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tada2a in Genome Data Viewer
    Location:
    10q26
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (69463966..69511612, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (68966502..69014149, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (71393701..71441435, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene synergin, gamma Neighboring gene uncharacterized LOC134480839 Neighboring gene ribosomal protein S15a, pseudogene 2 Neighboring gene dual specificity phosphatase 14 Neighboring gene similar to human chromosome 17 open reading frame 78 Neighboring gene acetyl-CoA carboxylase alpha Neighboring gene ribosomal protein L17, pseudogene 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10. Saad Y, et al. Genomics, 2007 Mar. PMID 17218081, Free PMC Article
    2. Histone-like TAFs within the PCAF histone acetylase complex. Ogryzko VV, et al. Cell, 1998 Jul 10. PMID 9674425
    3. The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates. Orpinell M, et al. EMBO J, 2010 Jul 21. PMID 20562830, Free PMC Article
    4. ATAC-king the complexity of SAGA during evolution. Spedale G, et al. Genes Dev, 2012 Mar 15. PMID 22426530, Free PMC Article
    5. ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes. Krebs AR, et al. EMBO Rep, 2010 Jul. PMID 20508642, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromatin organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein stability IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of tubulin deacetylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of tubulin deacetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of tubulin deacetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of ATAC complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ATAC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SAGA complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SAGA-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcriptional adapter 2-alpha
    Names
    ADA2-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012141.1 → NP_001012141.1  transcriptional adapter 2-alpha

      See identical proteins and their annotated locations for NP_001012141.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079084
      UniProtKB/Swiss-Prot
      A1EC76, Q6AYE3
      UniProtKB/TrEMBL
      A0A8I6ABC7
      Related
      ENSRNOP00000003699.6, ENSRNOT00000003699.7
      Conserved Domains (1) summary
      COG5114
      Location:28 → 440
      COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      69463966..69511612 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247041.4 → XP_006247103.1  transcriptional adapter 2-alpha isoform X2

      UniProtKB/TrEMBL
      A0A0G2K0R7, A0A8I6ABC7
      Related
      ENSRNOP00000071555.2, ENSRNOT00000087769.3
      Conserved Domains (4) summary
      COG5114
      Location:28 → 420
      COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
      cd00167
      Location:54 → 98
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam04433
      Location:354 → 420
      SWIRM; SWIRM domain
      cl00295
      Location:15 → 44
      ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...

    2. XM_063269382.1 → XP_063125452.1  transcriptional adapter 2-alpha isoform X7

    3. XM_039086364.2 → XP_038942292.1  transcriptional adapter 2-alpha isoform X6

      Conserved Domains (1) summary
      COG5114
      Location:28 → 320
      COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

    4. XM_039086363.1 → XP_038942291.1  transcriptional adapter 2-alpha isoform X4

      UniProtKB/TrEMBL
      A0A8L2UHP0
      Conserved Domains (1) summary
      COG5114
      Location:4 → 396
      COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

    5. XM_006247042.4 → XP_006247104.1  transcriptional adapter 2-alpha isoform X3

      UniProtKB/TrEMBL
      A0A8L2UHP0
      Related
      ENSRNOP00000089252.1, ENSRNOT00000119062.2
      Conserved Domains (4) summary
      COG5114
      Location:4 → 416
      COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
      cd00167
      Location:50 → 94
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      cd02335
      Location:3 → 40
      ZZ_ADA2; Zinc finger, ZZ type. Zinc finger present in ADA2, a putative transcriptional adaptor, and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
      pfam04433
      Location:350 → 416
      SWIRM; SWIRM domain

    6. XM_039086362.2 → XP_038942290.1  transcriptional adapter 2-alpha isoform X1

      UniProtKB/Swiss-Prot
      A1EC76, Q6AYE3
      UniProtKB/TrEMBL
      A0A8I6ABC7
      Conserved Domains (1) summary
      COG5114
      Location:28 → 440
      COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

    7. XM_039086365.2 → XP_038942293.1  transcriptional adapter 2-alpha isoform X8

      Conserved Domains (1) summary
      COG5114
      Location:1 → 276
      COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

    8. XM_063269381.1 → XP_063125451.1  transcriptional adapter 2-alpha isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AYE3.1 GenPept UniProtKB/Swiss-Prot:Q6AYE3

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