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    CTSC cathepsin C [ Bos taurus (domestic cattle) ]

    Gene ID: 352958, updated on 4-Oct-2024

    Summary

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    Official Symbol
    CTSCprovided by VGNC
    Official Full Name
    cathepsin Cprovided by VGNC
    Primary source
    VGNC:VGNC:27814
    See related
    BGD:BT28669; Ensembl:ENSBTAG00000011100
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See CTSC in Genome Data Viewer
    Location:
    chromosome: 29
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 29 NC_037356.1 (7375381..7415746)

    Chromosome 29 - NC_037356.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112444873 Neighboring gene histone H2B type 1-K Neighboring gene uncharacterized LOC104976218 Neighboring gene RAB38, member RAS oncogene family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037356.1 Chromosome 29 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cathepsin H is an additional convertase of pro-granzyme B. D'Angelo ME, et al. J Biol Chem, 2010 Jul 2. PMID 20435891, Free PMC Article
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC126959

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis involved in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dipeptidyl peptidase 1
    Names
    DPP-I
    DPPI
    cathepsin J
    dipeptidyl peptidase I
    dipeptidyl transferase
    NP_001028789.1
    XP_010819111.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033617.2 → NP_001028789.1  dipeptidyl peptidase 1 precursor

      See identical proteins and their annotated locations for NP_001028789.1

      Status: PROVISIONAL

      Source sequence(s)
      BC102115
      UniProtKB/Swiss-Prot
      Q3ZCJ8
      UniProtKB/TrEMBL
      Q864S1
      Related
      ENSBTAP00000014735.4, ENSBTAT00000014735.6
      Conserved Domains (2) summary
      cd02621
      Location:231 → 460
      Peptidase_C1A_CathepsinC; Cathepsin C; also known as Dipeptidyl Peptidase I (DPPI), an atypical papain-like cysteine peptidase with chloride dependency and dipeptidyl aminopeptidase activity, resulting from its tetrameric structure which limits substrate access. Each subunit of ...
      pfam08773
      Location:26 → 138
      CathepsinC_exc; Cathepsin C exclusion domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037356.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      7375381..7415746
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010820809.4 → XP_010819111.1  dipeptidyl peptidase 1 isoform X1

      UniProtKB/TrEMBL
      A0AAA9T2L4
      Related
      ENSBTAP00000091973.1, ENSBTAT00000127306.1
      Conserved Domains (1) summary
      pfam08773
      Location:26 → 106
      CathepsinC_exc; Cathepsin C exclusion domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3ZCJ8.1 GenPept UniProtKB/Swiss-Prot:Q3ZCJ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials