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    APOC1P1 apolipoprotein C1 pseudogene 1 [ Homo sapiens (human) ]

    Gene ID: 342, updated on 22-Oct-2024

    Summary

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    Official Symbol
    APOC1P1provided by HGNC
    Official Full Name
    apolipoprotein C1 pseudogene 1provided by HGNC
    Primary source
    HGNC:HGNC:608
    See related
    Ensembl:ENSG00000291128 AllianceGenome:HGNC:608
    Gene type
    pseudo
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APOC1P; ApoC-IA
    Expression
    Restricted expression toward liver (RPKM 82.5) See more
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    Genomic context

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    See APOC1P1 in Genome Data Viewer
    Location:
    19q13.32
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (44926803..44931386)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (47739399..47756085)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (45430060..45434643)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45408370-45409172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45409975-45410777 Neighboring gene apolipoprotein E Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45415901-45416660 Neighboring gene APOC1 promoter region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45418179-45418936 Neighboring gene apolipoprotein C1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45430599-45431491 Neighboring gene APOC4-APOC2 readthrough (NMD candidate) Neighboring gene apolipoprotein C4 Neighboring gene apolipoprotein C2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Expression of lncRNAs AK058003 and APOC1P1 in breast cancer patients. Rajabi A, et al. Nucleosides Nucleotides Nucleic Acids, 2022. PMID 35580209
    2. Identification of Long Noncoding RNA APOC1P1 as an Oncogene in Clear Cell Renal Cell Carcinoma. Sun C, et al. Dis Markers, 2019. PMID 31871500, Free PMC Article
    3. Long intergenic non-coding RNA APOC1P1-3 inhibits apoptosis by decreasing α-tubulin acetylation in breast cancer. Liao XH, et al. Cell Death Dis, 2016 May 26. PMID 27228351, Free PMC Article
    4. Two copies of the human apolipoprotein C-I gene are linked closely to the apolipoprotein E gene. Lauer SJ, et al. J Biol Chem, 1988 May 25. PMID 2835369
    5. Detection of two distinct forms of apoC-I in great apes. Puppione DL, et al. Comp Biochem Physiol Part D Genomics Proteomics, 2010 Mar. PMID 20209111, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of lncRNAs AK058003 and APOC1P1 in breast cancer patients.
      Title: Expression of lncRNAs AK058003 and APOC1P1 in breast cancer patients.
    2. Study have identified elevated LncRNA APOC1P1 expression in clear cell renal cell carcinoma (ccRCC) and indicated that LncRNA APOC1P1 expression was significantly associated with overall survival. LncRNA APOC1P1 plays an important role in the onset and progression of ccRCC by affecting cell proliferation and invasion. As a proto-oncogene, It can be considered a prognostic biomarker in ccRCC patients.
      Title: Identification of Long Noncoding RNA APOC1P1 as an Oncogene in Clear Cell Renal Cell Carcinoma.
    3. Long intergenic non-coding RNA APOC1P1-3 inhibits apoptosis by decreasing alpha-tubulin acetylation in breast cancer.
      Title: Long intergenic non-coding RNA APOC1P1-3 inhibits apoptosis by decreasing α-tubulin acetylation in breast cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
    EBI GWAS Catalog

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Homology

    Other Names

    • apolipoprotein C-I pseudogene 1
    • lincRNA-APOC1P1-3

    Clone Names

    • DKFZp781C1677

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_028412.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AC011481, AV645786, DA638554
      Related
      ENST00000574565.2

    2. NR_028413.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate internal splice site and is shorter, compared to variant 1.
      Source sequence(s)
      AC011481, CB162526, DA638554
      Related
      ENST00000575148.8

    3. NR_028414.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate internal segment, uses an alternate internal splice site and is shorter, compared to variant 1.
      Source sequence(s)
      AC011481, DA636997, DA638554
      Related
      ENST00000507983.7

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      44926803..44931386
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      47739399..47756085
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_009854.1: Suppressed sequence

      Description
      NG_009854.1: This RefSeq was permanently suppressed because it is now thought that this gene is a transcribed pseudogene.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials