Gpbar1 G protein-coupled bile acid receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpbar1provided by RGD
Official Full Name: G protein-coupled bile acid receptor 1provided by RGD
Primary source: RGD:631400
See related: EnsemblRapid:ENSRNOG00000087111 AllianceGenome:RGD:631400
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tgr5; M-BAR
Summary: Enables G protein-coupled receptor activity. Involved in positive regulation of ERK1 and ERK2 cascade and positive regulation of cholangiocyte proliferation. Predicted to be located in cytoplasm. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Biomarker of metabolic dysfunction-associated steatohepatitis and polycystic kidney disease. Orthologous to human GPBAR1 (G protein-coupled bile acid receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 11.0), Lung (RPKM 9.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q33

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (83309895..83312397)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (75860758..75863260)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (81555914..81560931)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Changes in the Bile Acid Pool and Timing of Female Puberty: Potential Novel Role of Hypothalamic TGR5.
Title: Changes in the Bile Acid Pool and Timing of Female Puberty: Potential Novel Role of Hypothalamic TGR5.
The function of the gut microbiota-bile acid-TGR5 axis in diarrhea-predominant irritable bowel syndrome.
Title: The function of the gut microbiota-bile acid-TGR5 axis in diarrhea-predominant irritable bowel syndrome.
TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats.
Title: TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats.
Bile acid toxicity in Paneth cells contributes to gut dysbiosis induced by high-fat feeding.
Title: Bile acid toxicity in Paneth cells contributes to gut dysbiosis induced by high-fat feeding.
Satiety induced by bile acids is mediated via vagal afferent pathways.
Title: Satiety induced by bile acids is mediated via vagal afferent pathways.
Activation of TGR5 restores AQP2 expression via the HIF pathway in renal ischemia-reperfusion injury.
Title: Activation of TGR5 restores AQP2 expression via the HIF pathway in renal ischemia-reperfusion injury.
Overexpression of TGR5 alleviates myocardial ischemia/reperfusion injury via AKT/GSK-3beta mediated inflammation and mitochondrial pathway.
Title: Overexpression of TGR5 alleviates myocardial ischemia/reperfusion injury via AKT/GSK-3β mediated inflammation and mitochondrial pathway.
Hepatic Bile Acid Reuptake in the Rat Depends on Bile Acid Conjugation but Not on Agonistic Properties towards FXR and TGR5.
Title: Hepatic Bile Acid Reuptake in the Rat Depends on Bile Acid Conjugation but Not on Agonistic Properties towards FXR and TGR5.
Activation of TGR5 protects blood brain barrier via the BRCA1/Sirt1 pathway after middle cerebral artery occlusion in rats.
Title: Activation of TGR5 protects blood brain barrier via the BRCA1/Sirt1 pathway after middle cerebral artery occlusion in rats.
expression in intestine decreased during progression of glucose intolerance
Title: The relationship between bile acid concentration, glucagon-like-peptide 1, fibroblast growth factor 15 and bile acid receptors in rats during progression of glucose intolerance.

Submit: New GeneRIF Correction See all GeneRIFs (22)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled bile acid receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled bile acid receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to bile acid	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cholangiocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: G-protein coupled bile acid receptor 1

Names: G protein-coupled receptor; membrane-type receptor for bile acids

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.