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    Ppp1r13l protein phosphatase 1, regulatory subunit 13 like [ Mus musculus (house mouse) ]

    Gene ID: 333654, updated on 2-Nov-2024

    Summary

    Official Symbol
    Ppp1r13lprovided by MGI
    Official Full Name
    protein phosphatase 1, regulatory subunit 13 likeprovided by MGI
    Primary source
    MGI:MGI:3525053
    See related
    Ensembl:ENSMUSG00000040734 AllianceGenome:MGI:3525053
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    wa3; IASPP; Nkip1
    Summary
    Predicted to enable identical protein binding activity. Involved in negative regulation of inflammatory response. Acts upstream of or within several processes, including cardiac muscle contraction; heart development; and negative regulation of transcription by RNA polymerase II. Predicted to be located in cell junction; cytosol; and intercellular bridge. Is expressed in esophagus; sensory organ; submandibular gland primordium; and vibrissa. Used to study arrhythmogenic right ventricular cardiomyopathy. Orthologous to human PPP1R13L (protein phosphatase 1 regulatory subunit 13 like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 16.3), stomach adult (RPKM 11.1) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ppp1r13l in Genome Data Viewer
    Location:
    7 A3; 7 9.62 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19093639..19112465)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19359724..19378540)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D830036C21 gene Neighboring gene VISTA enhancer mm567 Neighboring gene STARR-positive B cell enhancer ABC_E10427 Neighboring gene STARR-positive B cell enhancer ABC_E1719 Neighboring gene excision repair cross-complementing rodent repair deficiency, complementation group 1 Neighboring gene STARR-positive B cell enhancer ABC_E6519 Neighboring gene RNA polymerase I subunit G Neighboring gene STARR-seq mESC enhancer starr_18201 Neighboring gene STARR-positive B cell enhancer mm9_chr7:19967137-19967438 Neighboring gene excision repair cross-complementing rodent repair deficiency, complementation group 2 Neighboring gene microRNA 343 Neighboring gene kinesin light chain 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cardiac muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cardiac right ventricle morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic camera-type eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hair cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organismal-level homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within ventricular cardiac muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    relA-associated inhibitor
    Names
    NFkB interacting protein 1
    PPP1R13B-like protein
    inhibitor of ASPP protein
    protein iASPP
    protein phosphatase 1, regulatory (inhibitor) subunit 13 like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001010836.4NP_001010836.1  relA-associated inhibitor

      See identical proteins and their annotated locations for NP_001010836.1

      Status: VALIDATED

      Source sequence(s)
      AC118017, AC148988
      Consensus CDS
      CCDS20899.1
      UniProtKB/Swiss-Prot
      Q5I1X5
      UniProtKB/TrEMBL
      Q3TCU2
      Related
      ENSMUSP00000047839.8, ENSMUST00000047621.14
      Conserved Domains (4) summary
      cd11952
      Location:757813
      SH3_iASPP; Src Homology 3 (SH3) domain of Inhibitor of ASPP protein (iASPP)
      PHA03247
      Location:46364
      PHA03247; large tegument protein UL36; Provisional
      sd00045
      Location:627653
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:627713
      Ank_2; Ankyrin repeats (3 copies)
    2. NM_001419335.1NP_001406264.1  relA-associated inhibitor

      Status: VALIDATED

      Source sequence(s)
      AC118017, AC148988
      UniProtKB/Swiss-Prot
      Q5I1X5
      UniProtKB/TrEMBL
      Q3TCU2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      19093639..19112465
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540128.4XP_006540191.1  relA-associated inhibitor isoform X1

      See identical proteins and their annotated locations for XP_006540191.1

      UniProtKB/Swiss-Prot
      Q5I1X5
      UniProtKB/TrEMBL
      Q3TCU2
      Conserved Domains (4) summary
      cd11952
      Location:757813
      SH3_iASPP; Src Homology 3 (SH3) domain of Inhibitor of ASPP protein (iASPP)
      PHA03247
      Location:46364
      PHA03247; large tegument protein UL36; Provisional
      sd00045
      Location:627653
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:627713
      Ank_2; Ankyrin repeats (3 copies)
    2. XM_006540126.3XP_006540189.1  relA-associated inhibitor isoform X1

      See identical proteins and their annotated locations for XP_006540189.1

      UniProtKB/Swiss-Prot
      Q5I1X5
      UniProtKB/TrEMBL
      Q3TCU2
      Conserved Domains (4) summary
      cd11952
      Location:757813
      SH3_iASPP; Src Homology 3 (SH3) domain of Inhibitor of ASPP protein (iASPP)
      PHA03247
      Location:46364
      PHA03247; large tegument protein UL36; Provisional
      sd00045
      Location:627653
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:627713
      Ank_2; Ankyrin repeats (3 copies)
    3. XM_036153184.1XP_036009077.1  relA-associated inhibitor isoform X1

      UniProtKB/Swiss-Prot
      Q5I1X5
      UniProtKB/TrEMBL
      Q3TCU2
      Conserved Domains (4) summary
      cd11952
      Location:757813
      SH3_iASPP; Src Homology 3 (SH3) domain of Inhibitor of ASPP protein (iASPP)
      PHA03247
      Location:46364
      PHA03247; large tegument protein UL36; Provisional
      sd00045
      Location:627653
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:627713
      Ank_2; Ankyrin repeats (3 copies)
    4. XM_006540127.5XP_006540190.1  relA-associated inhibitor isoform X1

      See identical proteins and their annotated locations for XP_006540190.1

      UniProtKB/Swiss-Prot
      Q5I1X5
      UniProtKB/TrEMBL
      Q3TCU2
      Conserved Domains (4) summary
      cd11952
      Location:757813
      SH3_iASPP; Src Homology 3 (SH3) domain of Inhibitor of ASPP protein (iASPP)
      PHA03247
      Location:46364
      PHA03247; large tegument protein UL36; Provisional
      sd00045
      Location:627653
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:627713
      Ank_2; Ankyrin repeats (3 copies)
    5. XM_030242701.2XP_030098561.1  relA-associated inhibitor isoform X1

      UniProtKB/Swiss-Prot
      Q5I1X5
      UniProtKB/TrEMBL
      Q3TCU2
      Conserved Domains (4) summary
      cd11952
      Location:757813
      SH3_iASPP; Src Homology 3 (SH3) domain of Inhibitor of ASPP protein (iASPP)
      PHA03247
      Location:46364
      PHA03247; large tegument protein UL36; Provisional
      sd00045
      Location:627653
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:627713
      Ank_2; Ankyrin repeats (3 copies)
    6. XM_030242700.2XP_030098560.1  relA-associated inhibitor isoform X1

      UniProtKB/Swiss-Prot
      Q5I1X5
      UniProtKB/TrEMBL
      Q3TCU2
      Conserved Domains (4) summary
      cd11952
      Location:757813
      SH3_iASPP; Src Homology 3 (SH3) domain of Inhibitor of ASPP protein (iASPP)
      PHA03247
      Location:46364
      PHA03247; large tegument protein UL36; Provisional
      sd00045
      Location:627653
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:627713
      Ank_2; Ankyrin repeats (3 copies)