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    brd3a bromodomain containing 3a [ Danio rerio (zebrafish) ]

    Gene ID: 327372, updated on 2-Nov-2024

    Summary

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    Official Symbol
    brd3aprovided by ZNC
    Official Full Name
    bromodomain containing 3aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6141
    See related
    Ensembl:ENSDARG00000006527 AllianceGenome:ZFIN:ZDB-GENE-030131-6141
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    brd3; fc01d09; fc74a08; fi36b10; wu:fa13h06; wu:fc01d09; wu:fc74a08; wu:fi04h10; wu:fi36b10
    Summary
    Predicted to enable lysine-acetylated histone binding activity. Acts upstream of or within thrombocyte differentiation. Predicted to be located in chromatin. Predicted to be active in nucleus. Orthologous to human BRD3 (bromodomain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See brd3a in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (18265014..18275337, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (18228378..18238701, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488794 Neighboring gene vav 2 guanine nucleotide exchange factor Neighboring gene uncharacterized LOC137488795 Neighboring gene WD repeat domain 5 Neighboring gene dynein, axonemal, intermediate chain 1, paralog 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolutionary history of the ABCB2 genomic region in teleosts. Palti Y, et al. Dev Comp Immunol, 2007. PMID 17055577
    2. Bromodomain and extraterminal (BET) proteins regulate biliary-driven liver regeneration. Ko S, et al. J Hepatol, 2016 Feb. PMID 26505118, Free PMC Article
    3. Characterization of the six zebrafish clade B fibrillar procollagen genes, with evidence for evolutionarily conserved alternative splicing within the pro-alpha1(V) C-propeptide. Hoffman GG, et al. Matrix Biol, 2010 May. PMID 20102740, Free PMC Article
    4. A loss of function screen of identified genome-wide association study Loci reveals new genes controlling hematopoiesis. Bielczyk-Maczyńska E, et al. PLoS Genet, 2014 Jul. PMID 25010335, Free PMC Article
    5. Bone morphogenetic protein signaling governs biliary-driven liver regeneration in zebrafish through tbx2b and id2a. Choi TY, et al. Hepatology, 2017 Nov. PMID 28599080, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0043

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables lysine-acetylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within thrombocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    bromodomain-containing protein 3a
    Names
    bromodomain containing 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001123389.3 → NP_001116861.1  bromodomain-containing protein 3a

      Status: VALIDATED

      Source sequence(s)
      FP102053
      UniProtKB/TrEMBL
      A0A8M1NGV5, F1QQP6
      Related
      ENSDARP00000117023.1, ENSDART00000135239.3
      Conserved Domains (3) summary
      cd05497
      Location:30 → 136
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:295 → 396
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:574 → 638
      BET; Bromodomain extra-terminal - transcription regulation

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      18265014..18275337 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068215790.1 → XP_068071891.1  bromodomain-containing protein 3a isoform X7

    2. XM_068215788.1 → XP_068071889.1  bromodomain-containing protein 3a isoform X3

    3. XM_068215789.1 → XP_068071890.1  bromodomain-containing protein 3a isoform X5

    4. XM_005161148.5 → XP_005161205.1  bromodomain-containing protein 3a isoform X1

      UniProtKB/TrEMBL
      A0A8M2B838
      Conserved Domains (3) summary
      cd05497
      Location:30 → 136
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:294 → 395
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:573 → 637
      BET; Bromodomain extra-terminal - transcription regulation

    5. XM_005161152.5 → XP_005161209.1  bromodomain-containing protein 3a isoform X6

      UniProtKB/TrEMBL
      A0A8M2B835
      Conserved Domains (3) summary
      cd05497
      Location:30 → 136
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:295 → 396
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:546 → 610
      BET; Bromodomain extra-terminal - transcription regulation

    6. XM_005161150.5 → XP_005161207.1  bromodomain-containing protein 3a isoform X2

      UniProtKB/TrEMBL
      A0A8M2B828
      Conserved Domains (3) summary
      cd05497
      Location:30 → 136
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:295 → 396
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:569 → 633
      BET; Bromodomain extra-terminal - transcription regulation

    7. XM_005161151.5 → XP_005161208.1  bromodomain-containing protein 3a isoform X4

      UniProtKB/TrEMBL
      A0A8M2B853
      Conserved Domains (3) summary
      cd05497
      Location:30 → 136
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:295 → 396
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:551 → 615
      BET; Bromodomain extra-terminal - transcription regulation
    Nucleotide Protein Strain
    Heading Accession and Version

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