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    Sidt1 SID1 transmembrane family, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 320007, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Sidt1provided by MGI
    Official Full Name
    SID1 transmembrane family, member 1provided by MGI
    Primary source
    MGI:MGI:2443155
    See related
    Ensembl:ENSMUSG00000022696 AllianceGenome:MGI:2443155
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B830021E24Rik
    Summary
    Enables double-stranded RNA binding activity. Predicted to be involved in RNA transport. Predicted to be located in membrane. Predicted to be active in lysosome and plasma membrane. Is expressed in intestine and male reproductive gland or organ. Orthologous to human SIDT1 (SID1 transmembrane family member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cortex adult (RPKM 11.4), bladder adult (RPKM 10.6) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sidt1 in Genome Data Viewer
    Location:
    16 B4; 16 28.57 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (44060540..44153575, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (44240177..44333212, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40895 Neighboring gene STARR-positive B cell enhancer ABC_E9932 Neighboring gene STARR-seq mESC enhancer starr_40896 Neighboring gene STARR-positive B cell enhancer ABC_E11613 Neighboring gene STARR-positive B cell enhancer ABC_E2462 Neighboring gene N(alpha)-acetyltransferase 50, NatE catalytic subunit Neighboring gene upstream transcription factor family member 3 Neighboring gene STARR-seq mESC enhancer starr_40897 Neighboring gene STARR-seq mESC enhancer starr_40898 Neighboring gene STARR-seq mESC enhancer starr_40899 Neighboring gene spindle and centriole associated protein 1 Neighboring gene STARR-seq mESC enhancer starr_40902 Neighboring gene cilia and flagella associated protein 44 Neighboring gene STARR-seq mESC enhancer starr_40903 Neighboring gene STARR-seq mESC enhancer starr_40904

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SIDT1 plays a key role in type I IFN responses to nucleic acids in plasmacytoid dendritic cells and mediates the pathogenesis of an imiquimod-induced psoriasis model. Morell M, et al. EBioMedicine, 2022 Feb. PMID 35065421, Free PMC Article
    2. Honeysuckle-derived microRNA2911 inhibits tumor growth by targeting TGF-β1. Liu C, et al. Chin Med, 2021 Jun 29. PMID 34187513, Free PMC Article
    3. SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs. Chen Q, et al. Cell Res, 2021 Mar. PMID 32801357, Free PMC Article
    4. SIDT1 Localizes to Endolysosomes and Mediates Double-Stranded RNA Transport into the Cytoplasm. Nguyen TA, et al. J Immunol, 2019 Jun 15. PMID 31061008
    5. Systemic RNA Interference Deficiency-1 (SID-1) Extracellular Domain Selectively Binds Long Double-stranded RNA and Is Required for RNA Transport by SID-1. Li W, et al. J Biol Chem, 2015 Jul 31. PMID 26067272, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SID1 transmembrane family member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159419.1 → NP_001152891.1  SID1 transmembrane family member 1 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK034344, AY562214, BC079584
      Consensus CDS
      CCDS49853.1
      UniProtKB/TrEMBL
      E9Q247
      Related
      ENSMUSP00000038433.7, ENSMUST00000047446.13
      Conserved Domains (1) summary
      pfam13965
      Location:187 → 811
      SID-1_RNA_chan; dsRNA-gated channel SID-1

    2. NM_198034.3 → NP_932151.2  SID1 transmembrane family member 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_932151.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      BC079584
      Consensus CDS
      CCDS28185.1
      UniProtKB/Swiss-Prot
      Q6AXF6, Q8R397
      Related
      ENSMUSP00000115372.2, ENSMUST00000136381.8
      Conserved Domains (1) summary
      pfam13965
      Location:187 → 806
      SID-1_RNA_chan; dsRNA-gated channel SID-1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      44060540..44153575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522237.2 → XP_006522300.1  SID1 transmembrane family member 1 isoform X2

      Conserved Domains (1) summary
      pfam13965
      Location:1 → 591
      SID-1_RNA_chan; dsRNA-gated channel SID-1

    2. XM_017317034.2 → XP_017172523.1  SID1 transmembrane family member 1 isoform X1

      Conserved Domains (1) summary
      pfam13965
      Location:127 → 754
      SID-1_RNA_chan; dsRNA-gated channel SID-1

    RNA

    1. XR_875822.3 RNA Sequence

    2. XR_384572.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AXF6.1 GenPept UniProtKB/Swiss-Prot:Q6AXF6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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