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    Tph2 tryptophan hydroxylase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317675, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tph2provided by RGD
    Official Full Name
    tryptophan hydroxylase 2provided by RGD
    Primary source
    RGD:631332
    See related
    EnsemblRapid:ENSRNOG00000003880 AllianceGenome:RGD:631332
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ntph
    Summary
    Predicted to enable tryptophan 5-monooxygenase activity. Involved in several processes, including cellular response to lithium ion; response to activity; and response to estrogen. Predicted to be active in neuron projection. Human ortholog(s) of this gene implicated in autistic disorder; major depressive disorder; and panic disorder. Orthologous to human TPH2 (tryptophan hydroxylase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 33.8), Testes (RPKM 9.4) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tph2 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (52571909..52676305, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (50685694..50789424, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (58042279..58149220, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093590 Neighboring gene basic transcription factor 3, pseudogene 10 Neighboring gene nuclear cap-binding protein subunit 2 pseudogene Neighboring gene TBC1 domain family, member 15 Neighboring gene uncharacterized LOC134479691 Neighboring gene RAB21, member RAS oncogene family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Tryptophan hydroxylase 2 gene expression and promoter polymorphisms in bipolar disorder and schizophrenia. De Luca V, et al. Psychopharmacology (Berl), 2005 Dec. PMID 16240163
    2. Daily rhythm of tryptophan hydroxylase-2 messenger ribonucleic acid within raphe neurons is induced by corticoid daily surge and modulated by enhanced locomotor activity. Malek ZS, et al. Endocrinology, 2007 Nov. PMID 17595225
    3. Cell-type specific induction of tryptophan hydroxylase-2 transcription by calcium mobilization. Remes Lenicov F, et al. J Neurochem, 2007 Dec. PMID 17868301
    4. Up-regulation of tryptophan hydroxylase-2 mRNA in the rat brain by chronic fluoxetine treatment correlates with its antidepressant effect. Shishkina GT, et al. Neuroscience, 2007 Dec 5. PMID 17950541
    5. Omega-3 fatty acid deficiency during perinatal development increases serotonin turnover in the prefrontal cortex and decreases midbrain tryptophan hydroxylase-2 expression in adult female rats: dissociation from estrogenic effects. McNamara RK, et al. J Psychiatr Res, 2009 Mar. PMID 18986658, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Poor Decision Making and Sociability Impairment Following Central Serotonin Reduction in Inducible TPH2-Knockdown Rats.
      Title: Poor Decision Making and Sociability Impairment Following Central Serotonin Reduction in Inducible TPH2-Knockdown Rats.
    2. The effect of brain serotonin deficit (TPH2-KO) on the expression and activity of liver cytochrome P450 enzymes in aging male Dark Agouti rats.
      Title: The effect of brain serotonin deficit (TPH2-KO) on the expression and activity of liver cytochrome P450 enzymes in aging male Dark Agouti rats.
    3. Molecular and cellular mechanisms of the first social relationship: A conserved role of 5-HT from mice to monkeys, upstream of oxytocin.
      Title: Molecular and cellular mechanisms of the first social relationship: A conserved role of 5-HT from mice to monkeys, upstream of oxytocin.
    4. The upregulation of tryptophan hydroxylase-2 expression is important for premature ejaculation treatment with the selective serotonin reuptake inhibitor.
      Title: The upregulation of tryptophan hydroxylase-2 expression is important for premature ejaculation treatment with the selective serotonin reuptake inhibitor.
    5. Crh receptor priming in the bed nucleus of the stria terminalis (BNST) induces tph2 gene expression in the dorsomedial dorsal raphe nucleus and chronic anxiety.
      Title: Crh receptor priming in the bed nucleus of the stria terminalis (BNST) induces tph2 gene expression in the dorsomedial dorsal raphe nucleus and chronic anxiety.
    6. Tph2 knock-out animals have a decreased 5-HT1A receptor sensitivity compared to wild-type animals.
      Title: Enhanced aggressive phenotype of Tph2 knockout rats is associated with diminished 5-HT(1A) receptor sensitivity.
    7. Chronic anxiety states are associated with dysregulated tph2 expression.
      Title: Elevated tph2 mRNA expression in a rat model of chronic anxiety.
    8. The data demonstrated that chronic elevation of corticosterone creates a vulnerability to a depression-like syndrome that is associated with increased tph2 expression, similar to that observed in depressed patients.
      Title: Chronic non-invasive corticosterone administration abolishes the diurnal pattern of tph2 expression.
    9. The results of this study indicate that TPH2 and serotonergic signaling may play an important role in the mesolimbic/mesocortical reward pathway.
      Title: TPH2 in the ventral tegmental area of the male rat brain.
    10. estrogen and TpH2 in the caudal dorsal raphe nucleus have a critical interaction in regulating anxiety-like behavior.
      Title: Overexpression or knockdown of rat tryptophan hyroxylase-2 has opposing effects on anxiety behavior in an estrogen-dependent manner.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tryptophan 5-monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tryptophan 5-monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tryptophan 5-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tryptophan 5-monooxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in aromatic amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to lithium ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to activity IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to calcium ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to estrogen IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to glucocorticoid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in serotonin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tryptophan 5-hydroxylase 2
    Names
    neuronal tryptophan hydroxylase
    tryptophan 5-monooxygenase 2
    NP_776211.1
    XP_063119759.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173839.3 → NP_776211.1  tryptophan 5-hydroxylase 2

      See identical proteins and their annotated locations for NP_776211.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q8CGU9
      UniProtKB/TrEMBL
      A6IGK2
      Related
      ENSRNOP00000005157.6, ENSRNOT00000005157.6
      Conserved Domains (3) summary
      TIGR01270
      Location:48 → 480
      Trp_5_monoox; tryptophan 5-monooxygenase, tetrameric
      cd04929
      Location:59 → 132
      ACT_TPH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tryptophan hydroxylases (TPH), both peripheral (TPH1) and neuronal (TPH2) enzymes
      pfam00351
      Location:147 → 477
      Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      52571909..52676305 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263689.1 → XP_063119759.1  tryptophan 5-hydroxylase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q1S6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CGU9.1 GenPept UniProtKB/Swiss-Prot:Q8CGU9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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