Klk15 kallikrein related-peptidase 15 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klk15provided by MGI
Official Full Name: kallikrein related-peptidase 15provided by MGI
Primary source: MGI:MGI:2447533
See related: Ensembl:ENSMUSG00000055193 AllianceGenome:MGI:2447533
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein maturation. Predicted to be active in extracellular space and secretory granule. Orthologous to human KLK15 (kallikrein related peptidase 15). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in colon adult (RPKM 2.6), testis adult (RPKM 0.6) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 28.41 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (43578829..43589459)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (43929405..43940035)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in protein maturation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kallikrein-15

Names: kallikrein 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174865.2 → NP_777354.1 kallikrein-15 precursor

See identical proteins and their annotated locations for NP_777354.1

Status: VALIDATED

Source sequence(s)

AC134858

Consensus CDS

CCDS21187.1

UniProtKB/TrEMBL

Q3B856, Q8CGR4

Conserved Domains (1) summary

cd00190
Location:23 → 247

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

43578829..43589459

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006540953.2 → XP_006541016.1 kallikrein-15 isoform X1

See identical proteins and their annotated locations for XP_006541016.1

UniProtKB/TrEMBL

Q3B856, Q8CGR4

Related

ENSMUSP00000066969.4, ENSMUST00000068625.5

Conserved Domains (1) summary

cd00190
Location:23 → 247

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...