U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Polh DNA polymerase eta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316235, updated on 17-Aug-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Polhprovided by RGD
    Official Full Name
    DNA polymerase etaprovided by RGD
    Primary source
    RGD:1309893
    See related
    EnsemblRapid:ENSRNOG00000019195 AllianceGenome:RGD:1309893
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-directed DNA polymerase activity. Predicted to be involved in error-prone translesion synthesis and response to UV-C. Predicted to act upstream of or within cellular response to UV-C; postreplication repair; and pyrimidine dimer repair. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus; replication fork; and site of double-strand break. Human ortholog(s) of this gene implicated in xeroderma pigmentosum variant type. Orthologous to human POLH (DNA polymerase eta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 80.5), Spleen (RPKM 56.2) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Polh in Genome Data Viewer
    Location:
    9q12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (22275929..22310576)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (14778355..14813210)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (17163354..17198006)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene RNA polymerase I and III subunit C Neighboring gene exportin 5 Neighboring gene activated RNA polymerase II transcriptional coactivator p15 pseudogene Neighboring gene GTP binding protein 2 Neighboring gene ribosomal protein S2, pseudogene 6

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Complementation of defective translesion synthesis and UV light sensitivity in xeroderma pigmentosum variant cells by human and mouse DNA polymerase eta. Yamada A, et al. Nucleic Acids Res, 2000 Jul 1. PMID 10871396, Free PMC Article
    2. Werner syndrome protein interacts functionally with translesion DNA polymerases. Kamath-Loeb AS, et al. Proc Natl Acad Sci U S A, 2007 Jun 19. PMID 17563354, Free PMC Article
    3. Participation of mouse DNA polymerase iota in strand-biased mutagenic bypass of UV photoproducts and suppression of skin cancer. Dumstorf CA, et al. Proc Natl Acad Sci U S A, 2006 Nov 28. PMID 17114294, Free PMC Article
    4. Familial breast cancer and DNA repair genes: Insights into known and novel susceptibility genes from the GENESIS study, and implications for multigene panel testing. Girard E, et al. Int J Cancer, 2019 Apr 15. PMID 30303537, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-directed DNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA synthesis involved in DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cellular response to UV-C ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in error-prone translesion synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within postreplication repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within pyrimidine dimer repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to UV-C ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to radiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in replication fork IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in site of double-strand break IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    DNA polymerase eta
    Names
    DNA-directed DNA polymerase eta
    polymerase (DNA directed), eta (RAD 30 related)
    polymerase (DNA) eta
    NP_001101674.1
    XP_006244599.1
    XP_038939462.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108204.1 → NP_001101674.1  DNA polymerase eta

      See identical proteins and their annotated locations for NP_001101674.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473987
      UniProtKB/TrEMBL
      A6JIT0, D4ADZ0
      Related
      ENSRNOP00000026049.2, ENSRNOT00000026049.5
      Conserved Domains (2) summary
      cd01702
      Location:10 → 427
      PolY_Pol_eta; DNA Polymerase eta
      COG0389
      Location:8 → 325
      DinP; Nucleotidyltransferase/DNA polymerase involved in DNA repair [Replication, recombination and repair]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      22275929..22310576
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244537.3 → XP_006244599.1  DNA polymerase eta isoform X1

      UniProtKB/TrEMBL
      A0A8I6GBC6
      Related
      ENSRNOP00000083995.1, ENSRNOT00000099257.2
      Conserved Domains (2) summary
      pfam18439
      Location:471 → 501
      zf_UBZ; Ubiquitin-Binding Zinc Finger
      cl28996
      Location:52 → 290
      PolY; Y-family of DNA polymerases

    2. XM_039083534.2 → XP_038939462.1  DNA polymerase eta isoform X2

      Conserved Domains (2) summary
      pfam18439
      Location:360 → 390
      zf_UBZ; Ubiquitin-Binding Zinc Finger
      cl28996
      Location:1 → 179
      PolY; Y-family of DNA polymerases
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous