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    Abcc10 ATP binding cassette subfamily C member 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316231, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Abcc10provided by RGD
    Official Full Name
    ATP binding cassette subfamily C member 10provided by RGD
    Primary source
    RGD:1306696
    See related
    EnsemblRapid:ENSRNOG00000018863 AllianceGenome:RGD:1306696
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ABC-type glutathione S-conjugate transporter activity and ABC-type xenobiotic transporter activity. Predicted to be involved in leukotriene metabolic process; leukotriene transport; and transmembrane transport. Predicted to be located in basolateral plasma membrane. Predicted to be active in membrane. Orthologous to human ABCC10 (ATP binding cassette subfamily C member 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 30.1), Kidney (RPKM 27.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Abcc10 in Genome Data Viewer
    Location:
    9q12
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (22154811..22174743)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (14657242..14677178)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (17041351..17061263)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 318 Neighboring gene uncharacterized LOC120094785 Neighboring gene uncharacterized LOC134480556 Neighboring gene U6 spliceosomal RNA Neighboring gene delta like non-canonical Notch ligand 2 Neighboring gene tight junction associated protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transport of xenobiotics across the blood-brain barrier. Hagenbuch B, et al. News Physiol Sci, 2002 Dec. PMID 12433976
    2. Integral and associated lysosomal membrane proteins. Schröder B, et al. Traffic, 2007 Dec. PMID 17897319
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ABC-type glutathione S-conjugate transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ABC-type transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ABC-type xenobiotic transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in leukotriene metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukotriene transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xenobiotic transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ATP-binding cassette sub-family C member 10
    Names
    ATP-binding cassette, sub-family C (CFTR/MRP), member 10
    ATP-binding cassette, subfamily C (CFTR/MRP), member 10
    multidrug resistance-associated protein 7
    NP_001101671.1
    XP_038939448.1
    XP_038939449.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108201.1 → NP_001101671.1  ATP-binding cassette sub-family C member 10

      See identical proteins and their annotated locations for NP_001101671.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473987
      UniProtKB/TrEMBL
      A6JIR4, D3ZX04
      Related
      ENSRNOP00000025598.6, ENSRNOT00000025598.9
      Conserved Domains (5) summary
      cd03244
      Location:1246 → 1465
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:599 → 802
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      TIGR01271
      Location:211 → 1485
      CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
      cl00549
      Location:957 → 1190
      ABC_membrane; ABC transporter transmembrane region
      cl01709
      Location:1201 → 1274
      PBP2_NikA_DppA_OppA_like; The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      22154811..22174743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083521.2 → XP_038939449.1  ATP-binding cassette sub-family C member 10 isoform X2

      Conserved Domains (2) summary
      TIGR00957
      Location:201 → 910
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd18598
      Location:289 → 572
      ABC_6TM_MRP7_D1_like; Six-transmembrane helical domain 1 (TMD1) of multidrug resistance-associated protein 7, and similar proteins

    2. XM_039083520.2 → XP_038939448.1  ATP-binding cassette sub-family C member 10 isoform X1

      UniProtKB/TrEMBL
      D3ZX04
      Conserved Domains (1) summary
      TIGR00957
      Location:201 → 1323
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    RNA

    1. XR_005488894.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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