Abhd5 abhydrolase domain containing 5, lysophosphatidic acid acyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abhd5provided by RGD
Official Full Name: abhydrolase domain containing 5, lysophosphatidic acid acyltransferaseprovided by RGD
Primary source: RGD:1303237
See related: Ensembl:ENSRNOG00000000221 AllianceGenome:RGD:1303237
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CGI-58
Summary: Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity and carboxylic ester hydrolase activity. Acts upstream of or within lipid metabolic process. Located in lipid droplet. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 1 and neutral lipid storage disease. Orthologous to human ABHD5 (abhydrolase domain containing 5, lysophosphatidic acid acyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 135.9), Liver (RPKM 117.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (130877834..130903947)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (122000241..122026447)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (130973222..131001448)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

upregulation of Pnpla2 expression and activation of ATGL (due to an increase in ABHD5 and decrease in G0S2 levels), as well as a coordinated interplay of these genes with Lipe in mesenteric WAT, contribute, at least in part, to an increase in the concentration of circulating NEFA in rats with reduced fat mass.
Title: Upregulation of Pnpla2 and Abhd5 and downregulation of G0s2 gene expression in mesenteric white adipose tissue as a potential reason for elevated concentration of circulating NEFA after removal of retroperitoneal, epididymal, and inguinal adipose tissue.
in skeletal muscle, during contraction-induced muscle lipolysis, ATGL and CGI-58 strongly associate and that the PLIN proteins work together to regulate lipolysis
Title: Skeletal muscle PLIN proteins, ATGL and CGI-58, interactions at rest and following stimulated contraction.
CGI-58 interacts with perilipin and is localized to lipid droplets
Title: CGI-58 interacts with perilipin and is localized to lipid droplets. Possible involvement of CGI-58 mislocalization in Chanarin-Dorfman syndrome.
CGI-58 facilitates lipolysis in cooperation with perilipin and other factors, including lipases
Title: CGI-58 facilitates lipolysis on lipid droplets but is not involved in the vesiculation of lipid droplets caused by hormonal stimulation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables 1-acylglycerol-3-phosphate O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables 1-acylglycerol-3-phosphate O-acyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables carboxylic ester hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lipase activator activity	IEA Inferred from Electronic Annotation more info
enables lipase activator activity	ISO Inferred from Sequence Orthology more info
enables lysophosphatidic acid acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lysophosphatidic acid acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
NOT enables triglyceride lipase activity	ISO Inferred from Sequence Orthology more info
NOT enables triglyceride lipase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of sequestering of triglyceride	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of sequestering of triglyceride	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of sequestering of triglyceride	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of sequestering of triglyceride	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidic acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidic acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidic acid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of triglyceride catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of triglyceride catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of triglyceride catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of triglyceride catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in lipid droplet	IBA Inferred from Biological aspect of Ancestor more info
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 1-acylglycerol-3-phosphate O-acyltransferase ABHD5

Names: abhydrolase domain-containing protein 5; lipid droplet-binding protein CGI-58

NP_997689.1

EC 2.3.1.51

XP_006244169.1

EC 2.3.1.51

XP_006244170.1

EC 2.3.1.51

XP_017451193.1

EC 2.3.1.51

XP_038937599.1

EC 2.3.1.51

XP_038937600.1

EC 2.3.1.51

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212524.1 → NP_997689.1 1-acylglycerol-3-phosphate O-acyltransferase ABHD5

See identical proteins and their annotated locations for NP_997689.1

Status: PROVISIONAL

Source sequence(s)

AY550934

UniProtKB/Swiss-Prot

Q6QA69

UniProtKB/TrEMBL

A0A8L2PZE5, A6I477

Conserved Domains (1) summary

PLN02894
Location:3 → 347

PLN02894; hydrolase, alpha/beta fold family protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

130877834..130903947

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017595704.3 → XP_017451193.1 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform X2

UniProtKB/TrEMBL

A0A8I5Y666

Related

ENSRNOP00000077694.1

Conserved Domains (1) summary

PLN02894
Location:28 → 279

PLN02894; hydrolase, alpha/beta fold family protein
XM_006244107.4 → XP_006244169.1 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform X1

See identical proteins and their annotated locations for XP_006244169.1

UniProtKB/TrEMBL

A0A8I5Y666

Related

ENSRNOP00000000239.5

Conserved Domains (1) summary

PLN02894
Location:53 → 304

PLN02894; hydrolase, alpha/beta fold family protein
XM_039081671.2 → XP_038937599.1 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform X2

UniProtKB/TrEMBL

A0A8I5Y666

Conserved Domains (1) summary

PLN02894
Location:28 → 279

PLN02894; hydrolase, alpha/beta fold family protein
XM_039081672.2 → XP_038937600.1 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform X2

UniProtKB/TrEMBL

A0A8I5Y666

Conserved Domains (1) summary

PLN02894
Location:28 → 279

PLN02894; hydrolase, alpha/beta fold family protein
XM_006244108.5 → XP_006244170.1 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform X1

See identical proteins and their annotated locations for XP_006244170.1

UniProtKB/TrEMBL

A0A8I5Y666

Conserved Domains (1) summary

PLN02894
Location:53 → 304

PLN02894; hydrolase, alpha/beta fold family protein