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    Slc24a4 solute carrier family 24 member 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314396, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Slc24a4provided by RGD
    Official Full Name
    solute carrier family 24 member 4provided by RGD
    Primary source
    RGD:1305926
    See related
    EnsemblRapid:ENSRNOG00000006729 AllianceGenome:RGD:1305926
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nckx4
    Summary
    Predicted to enable calcium ion transmembrane transporter activity; calcium-dependent protein binding activity; and calmodulin binding activity. Predicted to be involved in several processes, including cellular response to high light intensity; cone photoresponse recovery; and monoatomic cation transmembrane transport. Predicted to act upstream of or within positive regulation of gene expression. Predicted to be located in several cellular components, including cone photoreceptor outer segment; cytoplasm; and vesicle. Predicted to be active in apical plasma membrane. Human ortholog(s) of this gene implicated in amelogenesis imperfecta hypomaturation type 2A5 and pigmentation disease. Orthologous to human SLC24A4 (solute carrier family 24 member 4). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Brain (RPKM 23.4), Lung (RPKM 22.9) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc24a4 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (127044470..127184684)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (121279590..121419811)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (126015799..126158727)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene LLP homolog, long-term synaptic facilitation factor, pseudogene 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit B1 Neighboring gene cleavage and polyadenylation specific factor 2 Neighboring gene Ras and Rab interactor 3 Neighboring gene uncharacterized LOC134479252 Neighboring gene legumain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of mutations in SLC24A4, encoding a potassium-dependent sodium/calcium exchanger, as a cause of amelogenesis imperfecta. Parry DA, et al. Am J Hum Genet, 2013 Feb 7. PMID 23375655, Free PMC Article
    2. Novel role for K+-dependent Na+/Ca2+ exchangers in regulation of cytoplasmic free Ca2+ and contractility in arterial smooth muscle. Dong H, et al. Am J Physiol Heart Circ Physiol, 2006 Sep. PMID 16617138
    3. Preferential expression of plasmalemmal K-dependent Na+/Ca2+ exchangers in neurons versus astrocytes. Kiedrowski L, et al. Neuroreport, 2002 Aug 27. PMID 12218699
    4. Critical roles for WDR72 in calcium transport and matrix protein removal during enamel maturation. Wang SK, et al. Mol Genet Genomic Med, 2015 Jul. PMID 26247047, Free PMC Article
    5. The Na(+)/Ca(2+) exchanger NCKX4 governs termination and adaptation of the mammalian olfactory response. Stephan AB, et al. Nat Neurosci, 2011 Nov 6. PMID 22057188, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mRNA encoding NCKX3 and NCKX4 was demonstrated by RT-PCR and Northern blot in both rat mesenteric and aortic smooth muscle providing evidence for their role in mediating vascular tone.
      Title: Novel role for K+-dependent Na+/Ca2+ exchangers in regulation of cytoplasmic free Ca2+ and contractility in arterial smooth muscle.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium, potassium:sodium antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium, potassium:sodium antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in amelogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcium ion export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcium ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to high light intensity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cone photoresponse recovery ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of smell ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of drinking behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in membrane repolarization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of olfactory nerve maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of phototransduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of regulation of eating behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of response to melanocyte-stimulating hormone ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to odorant ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sensory perception of smell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of smell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cone photoreceptor outer segment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sodium/potassium/calcium exchanger 4
    Names
    solute carrier family 24 (sodium/potassium/calcium exchanger), member 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401345.2 → NP_001388274.1  sodium/potassium/calcium exchanger 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A0G2K3S9
      Related
      ENSRNOP00000072760.1, ENSRNOT00000089840.3

    2. NM_001401346.2 → NP_001388275.1  sodium/potassium/calcium exchanger 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      127044470..127184684
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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