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    Klhl15 kelch-like family member 15 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314111, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Klhl15provided by RGD
    Official Full Name
    kelch-like family member 15provided by RGD
    Primary source
    RGD:1563101
    See related
    EnsemblRapid:ENSRNOG00000006515 AllianceGenome:RGD:1563101
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563101
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in negative regulation of double-strand break repair via homologous recombination and nuclear protein quality control by the ubiquitin-proteasome system. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 103. Orthologous to human KLHL15 (kelch like family member 15). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 61.1), Thymus (RPKM 51.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Klhl15 in Genome Data Viewer
    Location:
    Xq22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (62987762..63043980)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (58994726..59050207)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (63342277..63390915)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA21 Neighboring gene eukaryotic translation elongation factor 1 gamma, pseudogene 14 Neighboring gene solute carrier family 25 member 21, pseudogene 1 Neighboring gene similar to human chromosome X open reading frame 58

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection. Ferretti LP, et al. Nat Commun, 2016 Aug 26. PMID 27561354, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC189229

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of double-strand break repair via homologous recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nuclear protein quality control by the ubiquitin-proteasome system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear protein quality control by the ubiquitin-proteasome system ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear protein quality control by the ubiquitin-proteasome system ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 15
    Names
    kelch-like 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108021.2 → NP_001101491.1  kelch-like protein 15

      See identical proteins and their annotated locations for NP_001101491.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      D3ZA50
      Conserved Domains (4) summary
      PHA03098
      Location:33 → 576
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:417 → 474
      Kelch; KELCH repeat [structural motif]
      cd18244
      Location:1 → 137
      BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
      cd18454
      Location:128 → 235
      BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

    2. NM_001434052.1 → NP_001420981.1  kelch-like protein 15

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021

    3. NM_001434053.1 → NP_001420982.1  kelch-like protein 15

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021

    4. NM_001434054.1 → NP_001420983.1  kelch-like protein 15

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021

    5. NM_001434055.1 → NP_001420984.1  kelch-like protein 15

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021

    6. NM_001434057.1 → NP_001420986.1  kelch-like protein 15

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021

    7. NM_001434058.1 → NP_001420987.1  kelch-like protein 15

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      62987762..63043980
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017602042.3 → XP_017457531.1  kelch-like protein 15 isoform X1

      UniProtKB/Swiss-Prot
      D3ZA50
      Conserved Domains (4) summary
      PHA03098
      Location:33 → 576
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:417 → 474
      Kelch; KELCH repeat [structural motif]
      cd18244
      Location:1 → 137
      BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
      cd18454
      Location:128 → 235
      BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

    2. XM_063280000.1 → XP_063136070.1  kelch-like protein 15 isoform X1

      UniProtKB/Swiss-Prot
      D3ZA50

    3. XM_063279995.1 → XP_063136065.1  kelch-like protein 15 isoform X1

      UniProtKB/Swiss-Prot
      D3ZA50

    4. XM_063279999.1 → XP_063136069.1  kelch-like protein 15 isoform X1

      UniProtKB/Swiss-Prot
      D3ZA50

    5. XM_063280003.1 → XP_063136073.1  kelch-like protein 15 isoform X4

    6. XM_063280004.1 → XP_063136074.1  kelch-like protein 15 isoform X5

    7. XM_063279994.1 → XP_063136064.1  kelch-like protein 15 isoform X1

      UniProtKB/Swiss-Prot
      D3ZA50
      Related
      ENSRNOP00000008558.5, ENSRNOT00000008558.7

    8. XM_039099706.2 → XP_038955634.1  kelch-like protein 15 isoform X1

      UniProtKB/Swiss-Prot
      D3ZA50
      Conserved Domains (4) summary
      PHA03098
      Location:33 → 576
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:417 → 474
      Kelch; KELCH repeat [structural motif]
      cd18244
      Location:1 → 137
      BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
      cd18454
      Location:128 → 235
      BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

    9. XM_063279997.1 → XP_063136067.1  kelch-like protein 15 isoform X1

      UniProtKB/Swiss-Prot
      D3ZA50

    10. XM_063279998.1 → XP_063136068.1  kelch-like protein 15 isoform X1

      UniProtKB/Swiss-Prot
      D3ZA50

    11. XM_039099705.2 → XP_038955633.1  kelch-like protein 15 isoform X1

      UniProtKB/Swiss-Prot
      D3ZA50
      Conserved Domains (4) summary
      PHA03098
      Location:33 → 576
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:417 → 474
      Kelch; KELCH repeat [structural motif]
      cd18244
      Location:1 → 137
      BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
      cd18454
      Location:128 → 235
      BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

    12. XM_063279996.1 → XP_063136066.1  kelch-like protein 15 isoform X1

      UniProtKB/Swiss-Prot
      D3ZA50

    13. XM_017602041.3 → XP_017457530.1  kelch-like protein 15 isoform X1

      UniProtKB/Swiss-Prot
      D3ZA50
      Conserved Domains (4) summary
      PHA03098
      Location:33 → 576
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:417 → 474
      Kelch; KELCH repeat [structural motif]
      cd18244
      Location:1 → 137
      BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
      cd18454
      Location:128 → 235
      BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

    14. XM_063279993.1 → XP_063136063.1  kelch-like protein 15 isoform X1

      UniProtKB/Swiss-Prot
      D3ZA50

    15. XM_063280001.1 → XP_063136071.1  kelch-like protein 15 isoform X2

    16. XM_063279992.1 → XP_063136062.1  kelch-like protein 15 isoform X1

      UniProtKB/Swiss-Prot
      D3ZA50

    17. XM_063280002.1 → XP_063136072.1  kelch-like protein 15 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZA50.1 GenPept UniProtKB/Swiss-Prot:D3ZA50

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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