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    Stag2 STAG2 cohesin complex component [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313304, updated on 28-Oct-2024

    Summary

    Official Symbol
    Stag2provided by RGD
    Official Full Name
    STAG2 cohesin complex componentprovided by RGD
    Primary source
    RGD:1562042
    See related
    EnsemblRapid:ENSRNOG00000029885 AllianceGenome:RGD:1562042
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562042
    Summary
    Predicted to enable chromatin binding activity. Predicted to be involved in mitotic spindle assembly and sister chromatid cohesion. Predicted to act upstream of or within stem cell population maintenance. Predicted to be located in chromatin; mitotic spindle pole; and nuclear lumen. Predicted to be part of mitotic cohesin complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Holoprosencephaly 13, X-linked and Mullegama-Klein-Martinez syndrome. Orthologous to human STAG2 (STAG2 cohesin complex component). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Thymus (RPKM 365.0), Spleen (RPKM 294.2) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Stag2 in Genome Data Viewer
    Location:
    Xq35
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (125839660..125971209)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (120974687..121105677)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (128493603..128624418)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene THO complex subunit 2 Neighboring gene similar to 40S ribosomal protein S2 Neighboring gene X-linked inhibitor of apoptosis Neighboring gene U2 spliceosomal RNA Neighboring gene actin, beta, pseudogene 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    part_of cohesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cohesin complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
     
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    part_of mitotic cohesin complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    cohesin subunit SA-2
    Names
    stromal antigen 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001173507.2NP_001166978.1  cohesin subunit SA-2 isoform 1

      See identical proteins and their annotated locations for NP_001166978.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      D3ZXT2
      Related
      ENSRNOP00000044231.3, ENSRNOT00000044240.7
      Conserved Domains (2) summary
      pfam08514
      Location:157265
      STAG; STAG domain
      cl21454
      Location:116145
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    2. NM_001434040.1NP_001420969.1  cohesin subunit SA-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
    3. NM_001434041.1NP_001420970.1  cohesin subunit SA-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
    4. NM_001434042.1NP_001420971.1  cohesin subunit SA-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
    5. NM_001434043.1NP_001420972.1  cohesin subunit SA-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
    6. NM_001434044.1NP_001420973.1  cohesin subunit SA-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
    7. NM_001434045.1NP_001420974.1  cohesin subunit SA-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      125839660..125971209
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008773521.4XP_008771743.1  cohesin subunit SA-2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4D9
      Conserved Domains (1) summary
      pfam08514
      Location:157265
      STAG; STAG domain
    2. XM_039099694.2XP_038955622.1  cohesin subunit SA-2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4D9
      Conserved Domains (1) summary
      pfam08514
      Location:157265
      STAG; STAG domain
    3. XM_063279980.1XP_063136050.1  cohesin subunit SA-2 isoform X2

      UniProtKB/TrEMBL
      D3ZXT2
    4. XM_017602032.3XP_017457521.1  cohesin subunit SA-2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4D9
      Related
      ENSRNOP00000073004.1, ENSRNOT00000082970.3
      Conserved Domains (1) summary
      pfam08514
      Location:157265
      STAG; STAG domain
    5. XM_063279976.1XP_063136046.1  cohesin subunit SA-2 isoform X2

      UniProtKB/TrEMBL
      D3ZXT2
    6. XM_039099693.2XP_038955621.1  cohesin subunit SA-2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4D9
      Conserved Domains (1) summary
      pfam08514
      Location:157265
      STAG; STAG domain
    7. XM_063279977.1XP_063136047.1  cohesin subunit SA-2 isoform X2

      UniProtKB/TrEMBL
      D3ZXT2
    8. XM_063279975.1XP_063136045.1  cohesin subunit SA-2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4D9
    9. XM_063279978.1XP_063136048.1  cohesin subunit SA-2 isoform X2

      UniProtKB/TrEMBL
      D3ZXT2
    10. XM_006257503.5XP_006257565.1  cohesin subunit SA-2 isoform X1

      See identical proteins and their annotated locations for XP_006257565.1

      UniProtKB/TrEMBL
      A0A0G2K4D9
      Conserved Domains (1) summary
      pfam08514
      Location:157265
      STAG; STAG domain
    11. XM_063279979.1XP_063136049.1  cohesin subunit SA-2 isoform X2

      UniProtKB/TrEMBL
      D3ZXT2