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    Zer1 zyg-11 related, cell cycle regulator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311842, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zer1provided by RGD
    Official Full Name
    zyg-11 related, cell cycle regulatorprovided by RGD
    Primary source
    RGD:1310284
    See related
    EnsemblRapid:ENSRNOG00000025832 AllianceGenome:RGD:1310284
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zyg11bl; RGD1310284
    Summary
    Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and protein quality control for misfolded or incompletely synthesized proteins. Predicted to be part of Cul2-RING ubiquitin ligase complex. Orthologous to human ZER1 (zyg-11 related cell cycle regulator). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 171.9), Adrenal (RPKM 134.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zer1 in Genome Data Viewer
    Location:
    3p12
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (33767520..33806716, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (13369688..13397524, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (8662579..8690486, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene Set nuclear proto-oncogene Neighboring gene protein kinase N3 Neighboring gene zinc finger DHHC-type palmitoyltransferase 12 Neighboring gene TBC1 domain family, member 13 Neighboring gene endonuclease G Neighboring gene SPOUT domain containing methyltransferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation. Timms RT, et al. Science, 2019 Jul 5. PMID 31273098, Free PMC Article
    2. The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components. Vasudevan S, et al. EMBO Rep, 2007 Mar. PMID 17304241, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein quality control for misfolded or incompletely synthesized proteins ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul2-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein zer-1 homolog
    Names
    zer-1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100707.1 → NP_001094177.1  protein zer-1 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZMI1, F1LQI6
      Related
      ENSRNOP00000032154.4, ENSRNOT00000035002.7
      Conserved Domains (3) summary
      cd00020
      Location:529 → 655
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00034
      Location:82 → 104
      LRR_AMN1; leucine-rich repeat [structural motif]
      sd00043
      Location:575 → 612
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      33767520..33806716 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283936.1 → XP_063140006.1  protein zer-1 homolog isoform X2

      Related
      ENSRNOP00000103879.1, ENSRNOT00000169293.1

    2. XM_063283935.1 → XP_063140005.1  protein zer-1 homolog isoform X1

    3. XM_063283940.1 → XP_063140010.1  protein zer-1 homolog isoform X8

    4. XM_063283938.1 → XP_063140008.1  protein zer-1 homolog isoform X6

      Related
      ENSRNOP00000099203.1, ENSRNOT00000126573.1

    5. XM_063283937.1 → XP_063140007.1  protein zer-1 homolog isoform X3

    6. XM_008761657.4 → XP_008759879.1  protein zer-1 homolog isoform X10

      See identical proteins and their annotated locations for XP_008759879.1

      UniProtKB/TrEMBL
      A0A8I5ZMI1
      Conserved Domains (4) summary
      cd00020
      Location:516 → 642
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00033
      Location:281 → 324
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:82 → 104
      LRR_AMN1; leucine-rich repeat [structural motif]
      sd00043
      Location:562 → 599
      ARM; armadillo repeat [structural motif]

    7. XM_008761656.4 → XP_008759878.1  protein zer-1 homolog isoform X10

      See identical proteins and their annotated locations for XP_008759878.1

      UniProtKB/TrEMBL
      A0A8I5ZMI1
      Conserved Domains (4) summary
      cd00020
      Location:516 → 642
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00033
      Location:281 → 324
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:82 → 104
      LRR_AMN1; leucine-rich repeat [structural motif]
      sd00043
      Location:562 → 599
      ARM; armadillo repeat [structural motif]

    8. XM_039105229.2 → XP_038961157.1  protein zer-1 homolog isoform X12

      UniProtKB/TrEMBL
      A0A8I5ZMI1
      Conserved Domains (3) summary
      sd00033
      Location:281 → 324
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:82 → 104
      LRR_AMN1; leucine-rich repeat [structural motif]
      sd00043
      Location:560 → 597
      ARM; armadillo repeat [structural motif]

    9. XM_017591838.2 → XP_017447327.1  protein zer-1 homolog isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZMI1, A6JTV3
      Conserved Domains (4) summary
      cd00020
      Location:516 → 642
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00033
      Location:281 → 324
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:82 → 104
      LRR_AMN1; leucine-rich repeat [structural motif]
      sd00043
      Location:562 → 599
      ARM; armadillo repeat [structural motif]

    10. XM_063283941.1 → XP_063140011.1  protein zer-1 homolog isoform X9

    11. XM_017591837.2 → XP_017447326.2  protein zer-1 homolog isoform X5

    12. XM_063283939.1 → XP_063140009.1  protein zer-1 homolog isoform X7

      Related
      ENSRNOP00000093181.2, ENSRNOT00000102789.2

    13. XM_008761655.4 → XP_008759877.1  protein zer-1 homolog isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZMI1
      Conserved Domains (4) summary
      cd00020
      Location:546 → 672
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00033
      Location:311 → 354
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:112 → 134
      LRR_AMN1; leucine-rich repeat [structural motif]
      sd00043
      Location:592 → 629
      ARM; armadillo repeat [structural motif]

    14. XM_017591839.3 → XP_017447328.1  protein zer-1 homolog isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZMI1
      Conserved Domains (4) summary
      cd00020
      Location:516 → 642
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00033
      Location:281 → 324
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:82 → 104
      LRR_AMN1; leucine-rich repeat [structural motif]
      sd00043
      Location:562 → 599
      ARM; armadillo repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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