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    Frmd5 FERM domain containing 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311362, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Frmd5provided by RGD
    Official Full Name
    FERM domain containing 5provided by RGD
    Primary source
    RGD:1561554
    See related
    EnsemblRapid:ENSRNOG00000016189 AllianceGenome:RGD:1561554
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561554
    Summary
    Predicted to enable integrin binding activity and protein kinase binding activity. Predicted to be involved in several processes, including actomyosin structure organization; negative regulation of cell motility; and positive regulation of cell adhesion. Predicted to be located in adherens junction. Predicted to be active in cytoskeleton. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with eye movement abnormalities and ataxia. Orthologous to human FRMD5 (FERM domain containing 5). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Adrenal (RPKM 238.1), Heart (RPKM 199.6) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Frmd5 in Genome Data Viewer
    Location:
    3q35
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (128945812..129217134, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (108492099..108763715, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (113480780..113755286, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene microfibrillar-associated protein 1A Neighboring gene WD repeat domain 76 Neighboring gene uncharacterized LOC120101916 Neighboring gene ribosomal protein S4, X-linked, pseudogene 2 Neighboring gene barrier-to-autointegration factor-like Neighboring gene prohibitin 2, pseudogene 2 Neighboring gene golgi membrane protein 2 Neighboring gene uncharacterized LOC134486142 Neighboring gene CTD small phosphatase like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. FERM-containing protein FRMD5 is a p120-catenin interacting protein that regulates tumor progression. Wang T, et al. FEBS Lett, 2012 Sep 21. PMID 22846708
    2. FERM domain-containing protein FRMD5 regulates cell motility via binding to integrin β5 subunit and ROCK1. Hu J, et al. FEBS Lett, 2014 Nov 28. PMID 25448675
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FERM domain containing 5; FERM domain-containing protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430431.1 → NP_001417360.1  FERM domain containing 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    2. NM_001430432.1 → NP_001417361.1  FERM domain containing 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    3. NM_001430433.1 → NP_001417362.1  FERM domain containing 5 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      128945812..129217134 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008762214.4 → XP_008760436.2  FERM domain-containing protein 5 isoform X3

    2. XM_008762212.4 → XP_008760434.2  FERM domain-containing protein 5 isoform X11

      Related
      ENSRNOP00000094330.2, ENSRNOT00000105786.2

    3. XM_039106833.2 → XP_038962761.1  FERM domain-containing protein 5 isoform X6

      UniProtKB/TrEMBL
      A0A8I6G8G4
      Conserved Domains (3) summary
      smart00295
      Location:19 → 210
      B41; Band 4.1 homologues
      pfam08736
      Location:338 → 383
      FA; FERM adjacent (FA)
      cl17171
      Location:191 → 324
      PH-like; Pleckstrin homology-like domain

    4. XM_039106834.2 → XP_038962762.1  FERM domain-containing protein 5 isoform X8

      UniProtKB/TrEMBL
      A0A8I6G8G4
      Conserved Domains (3) summary
      smart00295
      Location:19 → 210
      B41; Band 4.1 homologues
      pfam08736
      Location:338 → 383
      FA; FERM adjacent (FA)
      cl17171
      Location:191 → 324
      PH-like; Pleckstrin homology-like domain

    5. XM_008762213.4 → XP_008760435.2  FERM domain-containing protein 5 isoform X12

      UniProtKB/TrEMBL
      A0A8I6G8G4
      Related
      ENSRNOP00000081807.2, ENSRNOT00000111408.2

    6. XM_063284976.1 → XP_063141046.1  FERM domain-containing protein 5 isoform X9

      UniProtKB/TrEMBL
      A0A8I6B053
      Related
      ENSRNOP00000043316.6, ENSRNOT00000046659.7

    7. XM_039106827.2 → XP_038962755.1  FERM domain-containing protein 5 isoform X2

      UniProtKB/TrEMBL
      A0A8I6G8G4
      Conserved Domains (3) summary
      smart00295
      Location:19 → 210
      B41; Band 4.1 homologues
      pfam08736
      Location:333 → 378
      FA; FERM adjacent (FA)
      cl17171
      Location:191 → 319
      PH-like; Pleckstrin homology-like domain

    8. XM_039106826.2 → XP_038962754.1  FERM domain-containing protein 5 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G8G4
      Related
      ENSRNOP00000102428.1, ENSRNOT00000171719.1
      Conserved Domains (3) summary
      smart00295
      Location:19 → 210
      B41; Band 4.1 homologues
      pfam08736
      Location:338 → 383
      FA; FERM adjacent (FA)
      cl17171
      Location:191 → 324
      PH-like; Pleckstrin homology-like domain

    9. XM_008762211.4 → XP_008760433.2  FERM domain-containing protein 5 isoform X5

      UniProtKB/TrEMBL
      A0A8I6G8G4
      Related
      ENSRNOP00000109013.1, ENSRNOT00000124753.1

    10. XM_063284978.1 → XP_063141048.1  FERM domain-containing protein 5 isoform X10

    11. XM_039106829.2 → XP_038962757.1  FERM domain-containing protein 5 isoform X4

      UniProtKB/TrEMBL
      A0A8I6G8G4
      Conserved Domains (3) summary
      smart00295
      Location:4 → 177
      B41; Band 4.1 homologues
      pfam08736
      Location:305 → 350
      FA; FERM adjacent (FA)
      cl17171
      Location:158 → 291
      PH-like; Pleckstrin homology-like domain

    12. XM_063284975.1 → XP_063141045.1  FERM domain-containing protein 5 isoform X7

    13. XM_063284977.1 → XP_063141047.1  FERM domain-containing protein 5 isoform X10

    14. XM_063284979.1 → XP_063141049.1  FERM domain-containing protein 5 isoform X13

    15. XM_039106836.2 → XP_038962764.1  FERM domain-containing protein 5 isoform X14

      Conserved Domains (2) summary
      pfam08736
      Location:116 → 161
      FA; FERM adjacent (FA)
      cl17171
      Location:50 → 102
      PH-like; Pleckstrin homology-like domain

    16. XM_063284980.1 → XP_063141050.1  FERM domain-containing protein 5 isoform X15

    17. XM_039106837.2 → XP_038962765.1  FERM domain-containing protein 5 isoform X14

      Conserved Domains (2) summary
      pfam08736
      Location:116 → 161
      FA; FERM adjacent (FA)
      cl17171
      Location:50 → 102
      PH-like; Pleckstrin homology-like domain

    RNA

    1. XR_010064879.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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