Pex11b peroxisomal biogenesis factor 11 beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pex11bprovided by RGD
Official Full Name: peroxisomal biogenesis factor 11 betaprovided by RGD
Primary source: RGD:1310353
See related: EnsemblRapid:ENSRNOG00000021216 AllianceGenome:RGD:1310353
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein homodimerization activity. Predicted to be involved in peroxisome fission and regulation of peroxisome size. Located in peroxisomal membrane. Human ortholog(s) of this gene implicated in peroxisome biogenesis disorder 14B. Orthologous to human PEX11B (peroxisomal biogenesis factor 11 beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 85.6), Adrenal (RPKM 69.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (186858222..186869814)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (184172041..184180972)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (198762138..198771040)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in peroxisome fission	IBA Inferred from Biological aspect of Ancestor more info
involved_in peroxisome fission	ISO Inferred from Sequence Orthology more info
involved_in peroxisome organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of peroxisome size	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in peroxisomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisomal membrane	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peroxisomal membrane protein 11B

Names: peroxisomal biogenesis factor 11b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025684.1 → NP_001020855.1 peroxisomal membrane protein 11B

See identical proteins and their annotated locations for NP_001020855.1

Status: PROVISIONAL

Source sequence(s)

BC098865

UniProtKB/TrEMBL

F7FA09, Q4KM24

Related

ENSRNOP00000028811.6, ENSRNOT00000028811.8

Conserved Domains (1) summary

pfam05648
Location:1 → 249

PEX11; Peroxisomal biogenesis factor 11 (PEX11)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

186858222..186869814

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063281887.1 → XP_063137957.1 peroxisomal membrane protein 11B isoform X3
XM_039102377.2 → XP_038958305.1 peroxisomal membrane protein 11B isoform X1

UniProtKB/TrEMBL

A0A8I5Y5E1, A0A8I5ZPC8

Related

ENSRNOP00000080337.1, ENSRNOT00000099341.2

Conserved Domains (1) summary

pfam05648
Location:4 → 235

PEX11; Peroxisomal biogenesis factor 11 (PEX11)
XM_039102378.2 → XP_038958306.1 peroxisomal membrane protein 11B isoform X2

Conserved Domains (1) summary

pfam05648
Location:1 → 126

PEX11; Peroxisomal biogenesis factor 11 (PEX11)