P2ry13 purinergic receptor P2Y13 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: P2ry13provided by RGD
Official Full Name: purinergic receptor P2Y13provided by RGD
Primary source: RGD:1302941
See related: EnsemblRapid:ENSRNOG00000029756 AllianceGenome:RGD:1302941
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: P2y13
Summary: Enables G protein-coupled purinergic nucleotide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within cellular response to organic cyclic compound. Predicted to be located in endoplasmic reticulum. Orthologous to human P2RY13 (purinergic receptor P2Y13). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 158.1), Thymus (RPKM 51.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q26

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (145620321..145624730, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (143470437..143476360, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (149429648..149432864, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

P2Y13 receptor involved in HIV-1 gp120 induced neuropathy in superior cervical ganglia through NLRP3 inflammasome activation.
Title: P2Y(13) receptor involved in HIV-1 gp120 induced neuropathy in superior cervical ganglia through NLRP3 inflammasome activation.
P2Y13 and P2X7 receptors modulate mechanically induced adenosine triphosphate release from mast cells.
Title: P2Y(13) and P2X(7) receptors modulate mechanically induced adenosine triphosphate release from mast cells.
Gene expression of the purinergic P2Y12 subtype was detected in rat retina during early postnatal days (P0 to P5), while expression levels of P2Y13 were low.
Title: P2Y(12) but not P2Y(13) Purinergic Receptor Controls Postnatal Rat Retinogenesis In Vivo.
the activation of P2Y13 receptor might be involved in the effect of ADP on [Ca(2+)]i in cultured dorsal spinal cord microglia
Title: P2Y13 receptor-mediated rapid increase in intracellular calcium induced by ADP in cultured dorsal spinal cord microglia.
P2Y13 receptors regulate DUSP2 expression and contribute to p38 signaling homeostasis and survival in granule neurons.
Title: Neuroprotection elicited by P2Y13 receptors against genotoxic stress by inducing DUSP2 expression and MAPK signaling recovery.
P2Y13 receptor in invloves in suppression of neuronal differentiation. P2Y13 receptor antagonists might be candidates for treatment of neurodegenerative diseases.
Title: Involvement of P2Y13 receptor in suppression of neuronal differentiation.
ADP-mediated intracellular calcium mobilization and Hex release in RBL-2H3 cells are via P2Y(1) and P2y13 receptors, respectively.
Title: P2Y(13) receptor is responsible for ADP-mediated degranulation in RBL-2H3 rat mast cells.
results show a previously unrecognized role of the purinergic P2Y13 receptor in the induction of the Nrf2/HO-1 antioxidant response and in protection against oxidative stress
Title: The purinergic P2Y(13) receptor activates the Nrf2/HO-1 axis and protects against oxidative stress-induced neuronal death.
rat P2rY13 receptor displays several similarities but also interesting differences with its human and mouse orthologs [P2Y(13)]
Title: Cloning, pharmacological characterisation and distribution of the rat G-protein-coupled P2Y(13) receptor.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled purinergic nucleotide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled purinergic nucleotide receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled purinergic nucleotide receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of adenylate cyclase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: P2Y purinoceptor 13

Names: purinergic receptor P2Y, G-protein coupled, 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002853.1 → NP_001002853.1 P2Y purinoceptor 13

See identical proteins and their annotated locations for NP_001002853.1

Status: PROVISIONAL

Source sequence(s)

AY639875

UniProtKB/Swiss-Prot

Q6GUG4

UniProtKB/TrEMBL

A6JVK3

Related

ENSRNOP00000047532.1, ENSRNOT00000051027.4

Conserved Domains (2) summary

cd14964
Location:28 → 55

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:28 → 309

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

145620321..145624730 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008760991.4 → XP_008759213.1 P2Y purinoceptor 13 isoform X1

See identical proteins and their annotated locations for XP_008759213.1

UniProtKB/Swiss-Prot

Q6GUG4

UniProtKB/TrEMBL

A6JVK3

Conserved Domains (2) summary

cd14964
Location:28 → 55

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:28 → 309

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily