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    Itgb2 integrin subunit beta 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309684, updated on 2-Nov-2024

    Summary

    Official Symbol
    Itgb2provided by RGD
    Official Full Name
    integrin subunit beta 2provided by RGD
    Primary source
    RGD:1305581
    See related
    EnsemblRapid:ENSRNOG00000001224 AllianceGenome:RGD:1305581
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cd18
    Summary
    Contributes to cell adhesion molecule binding activity. Involved in several processes, including leukocyte migration involved in inflammatory response; positive regulation of NF-kappaB transcription factor activity; and positive regulation of nitric oxide biosynthetic process. Located in cell surface. Used to study nephritis and pneumonia. Biomarker of allergic rhinitis. Human ortholog(s) of this gene implicated in coronary restenosis; leukocyte adhesion deficiency; and leukocyte adhesion deficiency 1. Orthologous to human ITGB2 (integrin subunit beta 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 497.4), Thymus (RPKM 258.5) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Itgb2 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (11061009..11097242, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (11061394..11097656, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (11777773..11815647, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene PTTG1 interacting protein Neighboring gene transfer RNA proline (anticodon AGG) 81 Neighboring gene uncharacterized LOC120099012 Neighboring gene SLX9 ribosome biogenesis factor Neighboring gene NME/NM23 nucleoside diphosphate kinase 2, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC116306

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ICAM-3 receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables amyloid-beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables amyloid-beta binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to cargo receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to cell adhesion molecule binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables complement component C3b binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within activated T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in amyloid-beta clearance ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular extravasation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular extravasation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to low-density lipoprotein particle stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endodermal cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in leukocyte cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in leukocyte cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in leukocyte cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in leukocyte migration involved in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neutrophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neutrophil migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phagocytosis, engulfment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of leukocyte adhesion to vascular endothelial cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neutrophil degranulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nitric oxide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of superoxide anion generation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor clustering ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of integrin alphaL-beta2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of integrin alphaM-beta2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of integrin alphaX-beta2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of integrin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    integrin beta-2
    Names
    CD18 leukocyte adhesion molecule
    integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1
    integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit)
    macrophage antigen 1 (mac-1) beta subunit)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037780.2NP_001032869.2  integrin beta-2 precursor

      See identical proteins and their annotated locations for NP_001032869.2

      Status: VALIDATED

      Source sequence(s)
      BC085817
      UniProtKB/TrEMBL
      A0A9K3Y824, A6JK86, B2RYB8, F7F4S8
      Related
      ENSRNOP00000001639.5, ENSRNOT00000001639.8
      Conserved Domains (3) summary
      smart00187
      Location:33447
      INB; Integrin beta subunits (N-terminal portion of extracellular region)
      pfam07965
      Location:622698
      Integrin_B_tail; Integrin beta tail domain
      pfam08725
      Location:723765
      Integrin_b_cyt; Integrin beta cytoplasmic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      11061009..11097242 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098729.2XP_038954657.1  integrin beta-2 isoform X1

      UniProtKB/TrEMBL
      A0A9K3Y824, A6JK86, B2RYB8, F7F4S8
      Related
      ENSRNOP00000082439.1, ENSRNOT00000119404.2
      Conserved Domains (3) summary
      smart00187
      Location:33447
      INB; Integrin beta subunits (N-terminal portion of extracellular region)
      pfam07965
      Location:622698
      Integrin_B_tail; Integrin beta tail domain
      pfam08725
      Location:723765
      Integrin_b_cyt; Integrin beta cytoplasmic domain
    2. XM_039098730.2XP_038954658.1  integrin beta-2 isoform X1

      UniProtKB/TrEMBL
      A0A9K3Y824, A6JK86, B2RYB8, F7F4S8
      Conserved Domains (3) summary
      smart00187
      Location:33447
      INB; Integrin beta subunits (N-terminal portion of extracellular region)
      pfam07965
      Location:622698
      Integrin_B_tail; Integrin beta tail domain
      pfam08725
      Location:723765
      Integrin_b_cyt; Integrin beta cytoplasmic domain
    3. XM_063279156.1XP_063135226.1  integrin beta-2 isoform X1

      UniProtKB/TrEMBL
      A0A9K3Y824, B2RYB8, F7F4S8