Tnks2 tankyrase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Tnks2provided by RGD
Full Name: tankyrase 2provided by RGD
Primary source: RGD:1305026
See related: EnsemblRapid:ENSRNOG00000052664 AllianceGenome:RGD:1305026
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable NAD+-protein poly-ADP-ribosyltransferase activity and enzyme binding activity. Predicted to be involved in several processes, including positive regulation of canonical Wnt signaling pathway; post-translational protein modification; and regulation of telomere maintenance. Predicted to act upstream of or within regulation of growth. Predicted to be located in nuclear envelope; pericentriolar material; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human TNKS2 (tankyrase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 716.3), Brain (RPKM 372.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q53

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (243980432..244033629)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (234567888..234621079)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	Unplaced Scaffold	NW_007906945.1 (98838..152861)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI599623 (e-PCR)
- UniSTS:249986

BF386861 (e-PCR)
- UniSTS:243865

RH130135 (e-PCR)
- UniSTS:213422

BF394203 (e-PCR)
- UniSTS:244710

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NAD+-protein ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of telomere maintenance via telomere lengthening	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of telomere capping	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of telomere capping	ISO Inferred from Sequence Orthology more info
involved_in protein auto-ADP-ribosylation	ISO Inferred from Sequence Orthology more info
involved_in protein localization to chromosome, telomeric region	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
involved_in protein poly-ADP-ribosylation	IEA Inferred from Electronic Annotation more info
involved_in protein poly-ADP-ribosylation	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within telomere maintenance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in pericentriolar material	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: poly [ADP-ribose] polymerase tankyrase-2

Names: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2; tankyrase-2-like

NP_001101077.2

EC 2.4.2.30

XP_038936561.1

EC 2.4.2.30

XP_038936562.1

EC 2.4.2.30

XP_063121260.1

EC 2.4.2.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107607.2 → NP_001101077.2 poly [ADP-ribose] polymerase tankyrase-2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A0G2JTB0

Related

ENSRNOP00000068637.2, ENSRNOT00000079808.3

Conserved Domains (8) summary

cd09524
Location:871 → 936

SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily

smart00454
Location:877 → 933

SAM; Sterile alpha motif

cd00204
Location:518 → 643

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd01438
Location:938 → 1160

tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...

pfam00644
Location:952 → 1155

PARP; Poly(ADP-ribose) polymerase catalytic domain

pfam12796
Location:530 → 622

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:28 → 78

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:528 → 556

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

243980432..244033629

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039080634.2 → XP_038936562.1 poly [ADP-ribose] polymerase tankyrase-2 isoform X2

UniProtKB/TrEMBL

D3ZRP5

Related

ENSRNOP00000073499.2, ENSRNOT00000085497.3

Conserved Domains (5) summary

PTZ00322
Location:27 → 113

PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional

PHA02876
Location:73 → 458

PHA02876; ankyrin repeat protein; Provisional

cd09524
Location:808 → 873

SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily

cd01438
Location:875 → 1097

tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...

sd00045
Location:528 → 556

ANK; ANK repeat [structural motif]
XM_039080633.2 → XP_038936561.1 poly [ADP-ribose] polymerase tankyrase-2 isoform X1

Related

ENSRNOP00000098656.1, ENSRNOT00000132955.1

Conserved Domains (5) summary

cd09524
Location:814 → 879

SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily

PHA03095
Location:437 → 745

PHA03095; ankyrin-like protein; Provisional

cd01438
Location:881 → 1103

tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...

sd00045
Location:471 → 499

ANK; ANK repeat [structural motif]

pfam13857
Location:364 → 415

Ank_5; Ankyrin repeats (many copies)
XM_063265190.1 → XP_063121260.1 poly [ADP-ribose] polymerase tankyrase-2 isoform X3