Inpp5f inositol polyphosphate-5-phosphatase F [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Inpp5fprovided by RGD
Full Name: inositol polyphosphate-5-phosphatase Fprovided by RGD
Primary source: RGD:1305777
See related: EnsemblRapid:ENSRNOG00000020388 AllianceGenome:RGD:1305777
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable phosphatase activity and protein homodimerization activity. Involved in negative regulation of peptidyl-serine phosphorylation. Acts upstream of or within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in several cellular components, including clathrin-coated pit; neuronal cell body; and recycling endosome. Predicted to be active in clathrin-coated endocytic vesicle and early endosome. Orthologous to human INPP5F (inositol polyphosphate-5-phosphatase F). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 170.7), Kidney (RPKM 149.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q37

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (192620891..192700681)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (183190480..183270276)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (200037749..200116524)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH142764 (e-PCR)
- UniSTS:232011

RH127856 (e-PCR)
- UniSTS:211166

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables inositol monophosphate 4-phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol phosphate 4-phosphatase activity	ISO Inferred from Sequence Orthology more info
NOT enables phosphatidylinositol phosphate 5-phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol phosphate 5-phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4-phosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adult locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress	ISO Inferred from Sequence Orthology more info
involved_in clathrin-dependent endocytosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of axon regeneration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IC Inferred by Curator more info	PubMed
involved_in negative regulation of tyrosine phosphorylation of STAT protein	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphatidylinositol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor recycling	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell motility	ISO Inferred from Sequence Orthology more info
involved_in regulation of endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of endocytic recycling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in clathrin-coated endocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in clathrin-coated endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated pit	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phosphatidylinositide phosphatase SAC2

Names: phosphatidylinositide phosphatase SAC2-like

NP_001101024.2

EC 3.1.3.-

XP_008758104.1

EC 3.1.3.-

XP_038934395.1

EC 3.1.3.-

XP_038934420.1

EC 3.1.3.-

XP_063119483.1

EC 3.1.3.-

XP_063119485.1

EC 3.1.3.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107554.1 → NP_001101024.2 phosphatidylinositide phosphatase SAC2

See identical proteins and their annotated locations for NP_001101024.2

Status: PROVISIONAL

Source sequence(s)

CH473956

UniProtKB/TrEMBL

A0A8I6A7M9, A6IA11, D3ZKG7

Related

ENSRNOP00000027630.6, ENSRNOT00000027630.7

Conserved Domains (2) summary

pfam02383
Location:50 → 414

Syja_N; SacI homology domain

pfam12456
Location:594 → 695

hSac2; Inositol phosphatase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

192620891..192700681

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039078467.2 → XP_038934395.1 phosphatidylinositide phosphatase SAC2 isoform X2

UniProtKB/TrEMBL

A0A8I6A7M9

Related

ENSRNOP00000088322.2, ENSRNOT00000099799.2

Conserved Domains (2) summary

COG5329
Location:50 → 566

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

pfam12456
Location:595 → 671

hSac2; Inositol phosphatase
XM_063263413.1 → XP_063119483.1 phosphatidylinositide phosphatase SAC2 isoform X1

UniProtKB/TrEMBL

A0A8I6AE13

Related

ENSRNOP00000090690.1, ENSRNOT00000118340.2
XM_008759882.4 → XP_008758104.1 phosphatidylinositide phosphatase SAC2 isoform X3

Conserved Domains (2) summary

pfam02383
Location:50 → 414

Syja_N; SacI homology domain

pfam12456
Location:594 → 628

hSac2; Inositol phosphatase
XM_063263415.1 → XP_063119485.1 phosphatidylinositide phosphatase SAC2 isoform X5
XM_039078492.2 → XP_038934420.1 phosphatidylinositide phosphatase SAC2 isoform X4

UniProtKB/TrEMBL

A0A8I5ZVI2, A6IA14

Related

ENSRNOP00000082760.1, ENSRNOT00000106183.2

Conserved Domains (1) summary

pfam12456
Location:3 → 73

hSac2; Inositol phosphatase