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    Wee1 WEE1 G2 checkpoint kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308937, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Wee1provided by RGD
    Official Full Name
    WEE1 G2 checkpoint kinaseprovided by RGD
    Primary source
    RGD:1307895
    See related
    EnsemblRapid:ENSRNOG00000010017 AllianceGenome:RGD:1307895
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein tyrosine kinase activity. Predicted to be involved in negative regulation of G2/M transition of mitotic cell cycle. Predicted to act upstream of or within several processes, including establishment of cell polarity; neuron projection morphogenesis; and peptidyl-tyrosine phosphorylation. Predicted to be located in nucleolus. Predicted to be active in cytoplasm and nucleus. Orthologous to human WEE1 (WEE1 G2 checkpoint kinase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 65.2), Thymus (RPKM 58.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wee1 in Genome Data Viewer
    Location:
    1q33
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (173605609..173632450)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (164173681..164197688)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (174765228..174790882)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene importin 7 Neighboring gene small nucleolar RNA, H/ACA box 23 Neighboring gene uncharacterized LOC134483773 Neighboring gene zinc finger protein 143 Neighboring gene RNA, U6 small nuclear 1168 Neighboring gene switching B-cell complex subunit SWAP70 Neighboring gene SET binding factor 2 Neighboring gene N-lysine methyltransferase KMT5A-like Neighboring gene Y box binding protein 1, pseudogene 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Temporal gradient in the clock gene and cell-cycle checkpoint kinase Wee1 expression along the gut. Polidarová L, et al. Chronobiol Int, 2009 May. PMID 19444744
    2. Correlation of Myc Expression with Wee1 Expression by Zanthoxylum acanthopodium in Cervical Carcinoma Histology. Ilyas S, et al. Pak J Biol Sci, 2022 Jan. PMID 36591933
    3. Maturation promoting factor destabilization facilitates postovulatory aging-mediated abortive spontaneous egg activation in rat. Prasad S, et al. Dev Growth Differ, 2016 Apr. PMID 26991553
    4. Expression of wee1 and its related cell cycle components in mouse early stage follicles. Park CE, et al. Cells Tissues Organs, 2004. PMID 15459478
    5. Mouse p87wee1 kinase is regulated by M-phase specific phosphorylation. Honda R, et al. Chromosome Res, 1995 Aug. PMID 7551544

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Correlation of Myc Expression with Wee1 Expression by Zanthoxylum acanthopodium in Cervical Carcinoma Histology.
      Title: Correlation of Myc Expression with Wee1 Expression by Zanthoxylum acanthopodium in Cervical Carcinoma Histology.
    2. Data suggest that the increase of Wee 1 tyrosine kinase but decrease of early mitotic inhibitor 2 level triggers maturation promoting factor (MPF) destabilization and thereby postovulatory aging-mediated abortive spontaneous egg activation in eggs.
      Title: Maturation promoting factor destabilization facilitates postovulatory aging-mediated abortive spontaneous egg activation in rat.
    3. identified the PI3K/Akt pathway, the cell-cycle regulator Wee1 kinase, and protein kinase C (PKC) as prospective regulatory nodes of neuronal excitability through modulation of the FGF14:Nav1.6 complex.
      Title: Identifying a kinase network regulating FGF14:Nav1.6 complex assembly using split-luciferase complementation.
    4. The regulation of Wee1 by SadA and SadB kinases is essential for the differentiation of polarized neurons.
      Title: Persistence of the cell-cycle checkpoint kinase Wee1 in SadA- and SadB-deficient neurons disrupts neuronal polarity.
    5. rhythmic profiles of the clock gene Wee1 expression within the epithelium from different parts of the rat gut exhibited a difference in phasing.
      Title: Temporal gradient in the clock gene and cell-cycle checkpoint kinase Wee1 expression along the gut.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105683

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within establishment of cell polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of G2/M transition of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within neuron projection morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    wee1-like protein kinase
    Names
    wee 1 homolog
    wee1 tyrosine kinase
    wee1A kinase
    NP_001012760.1
    XP_006230036.1
    XP_017444692.1
    XP_063119123.1
    XP_063119130.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012742.1 → NP_001012760.1  wee1-like protein kinase

      See identical proteins and their annotated locations for NP_001012760.1

      Status: PROVISIONAL

      Source sequence(s)
      BC090346
      UniProtKB/Swiss-Prot
      Q5EAN3, Q63802
      UniProtKB/TrEMBL
      A6I810
      Related
      ENSRNOP00000013362.3, ENSRNOT00000013362.7
      Conserved Domains (1) summary
      cd14138
      Location:292 → 567
      PTKc_Wee1a; Catalytic domain of the Protein Tyrosine Kinase, Wee1a

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      173605609..173632450
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229974.5 → XP_006230036.1  wee1-like protein kinase isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZT95
      Related
      ENSRNOP00000081602.1, ENSRNOT00000118795.2
      Conserved Domains (2) summary
      cd14138
      Location:292 → 567
      PTKc_Wee1a; Catalytic domain of the Protein Tyrosine Kinase, Wee1a
      pfam00069
      Location:298 → 568
      Pkinase; Protein kinase domain

    2. XM_063263053.1 → XP_063119123.1  wee1-like protein kinase isoform X1

      UniProtKB/Swiss-Prot
      Q5EAN3, Q63802
      UniProtKB/TrEMBL
      A6I810

    3. XM_063263060.1 → XP_063119130.1  wee1-like protein kinase isoform X3

    4. XM_017589203.3 → XP_017444692.1  wee1-like protein kinase isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63802.1 GenPept UniProtKB/Swiss-Prot:Q63802

    Gene LinkOut

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