Zfp667 zinc finger protein 667 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zfp667provided by RGD
Official Full Name: zinc finger protein 667provided by RGD
Primary source: RGD:1359114
See related: EnsemblRapid:ENSRNOG00000033906 AllianceGenome:RGD:1359114
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mip1; Znf667
Summary: Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human ZNF667 (zinc finger protein 667). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 46.1), Muscle (RPKM 39.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (76634897..76655133, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (67601803..67622041, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (71270101..71290337, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZNF667 that confers cytoprotection is a novel regulator of the rat Bax gene.
Title: ZNF667/Mipu1 is a novel anti-apoptotic factor that directly regulates the expression of the rat Bax gene in H9c2 cells.
Mip1 over-expression inhibited H2O2-induced apoptosis and upregulation of Fas induced by H2O2 in H9c2 myogenic cells.
Title: Mipu1 protects H9c2 myogenic cells from hydrogen peroxide-induced apoptosis through inhibition of the expression of the death receptor Fas.
Mipu1 is involved in HIF-1-mediate cytoprotection by inhibiting the expression of Bax and interfering activation of mitochondrial apoptotic pathway.
Title: Mipu1, a novel direct target gene, is involved in hypoxia inducible factor 1-mediated cytoprotection.
The H(2)O(2)-induced up-regulation of Mipu1 in H9c2 cardiomyocytes was mediated by cAMP/PKA-dependent CREB activation.
Title: Oxidative stress-mediated up-regulation of myocardial ischemic preconditioning up-regulated protein 1 gene expression in H9c2 cardiomyocytes is regulated by cyclic AMP-response element binding protein.
Results found that Mipu1 was highly expressed in the heart and brain of rats and was localized in the nucleus of H9c2 myogenic cells and lay the foundation for further study of the biological functions of Mipu1.
Title: Tissue expression and subcellular localization of Mipu1, a novel myocardial ischemia-related gene.
These results suggested that Mipu1 protein might act as a transcriptional repressor in mitogen-activated protein kinase (MAPK) signaling pathway to mediate cellular functions
Title: Mipu1, a novel rat zinc-finger protein, inhibits transcriptional activities of AP-1 and SRE in mitogen-activated protein kinase signaling pathway.
Results indicate that the GC boxes are essential for the activity of the Mipu1 minimal promoter activity
Title: Identification and characterization of the minimal promoter of Mipu1: the role of GC boxes in the regulation of basal transcription.

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General gene information

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Markers

RH134964 (e-PCR)
- UniSTS:218241

BF402458 (e-PCR)
- UniSTS:245927

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger protein 667

Names: myocardial ischemic preconditioning up-regulated protein 1; myocardial ischemic preconditioning upregulated 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008557.1 → NP_001008557.1 zinc finger protein 667

See identical proteins and their annotated locations for NP_001008557.1

Status: VALIDATED

Source sequence(s)

AY221750

UniProtKB/Swiss-Prot

Q5MYW4

Related

ENSRNOP00000061115.4, ENSRNOT00000063956.5

Conserved Domains (5) summary

smart00349
Location:14 → 74

KRAB; krueppel associated box

COG5048
Location:141 → 599

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:499 → 519

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam01352
Location:14 → 53

KRAB; KRAB box

pfam13465
Location:456 → 480

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

76634897..76655133 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006228189.4 → XP_006228251.1 zinc finger protein 667 isoform X1

See identical proteins and their annotated locations for XP_006228251.1

UniProtKB/Swiss-Prot

Q5MYW4

Conserved Domains (5) summary

smart00349
Location:14 → 74

KRAB; krueppel associated box

COG5048
Location:141 → 599

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:499 → 519

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam01352
Location:14 → 53

KRAB; KRAB box

pfam13465
Location:456 → 480

zf-H2C2_2; Zinc-finger double domain