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    Neto1 neuropilin and tolloid like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307206, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Neto1provided by RGD
    Official Full Name
    neuropilin and tolloid like 1provided by RGD
    Primary source
    RGD:1566269
    See related
    EnsemblRapid:ENSRNOG00000014006 AllianceGenome:RGD:1566269
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1566269
    Summary
    Predicted to enable ionotropic glutamate receptor binding activity. Predicted to be involved in learning or memory; modulation of chemical synaptic transmission; and protein localization to synapse. Predicted to act upstream of or within receptor localization to synapse. Predicted to be located in excitatory synapse. Predicted to be active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density membrane. Orthologous to human NETO1 (neuropilin and tolloid like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 85.5) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Neto1 in Genome Data Viewer
    Location:
    18q12.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (81905455..82028730)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (79635633..79753913)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (83471342..83585043)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene F-box protein 15 Neighboring gene rho-related GTP-binding protein RhoG-like Neighboring gene ATP binding cassette subfamily G member 2, pseudogene 1 Neighboring gene enolase 1, pseudogene 27 Neighboring gene uncharacterized LOC120098158 Neighboring gene U1 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Development of Cortical Pyramidal Cell and Interneuronal Dendrites: a Role for Kainate Receptor Subunits and NETO1. Jack A, et al. Mol Neurobiol, 2019 Jul. PMID 30421168
    2. The auxiliary subunits Neto1 and Neto2 have distinct, subunit-dependent effects at recombinant GluK1- and GluK2-containing kainate receptors. Fisher JL. Neuropharmacology, 2015 Dec. PMID 26277340, Free PMC Article
    3. Neto1 associates with the NMDA receptor/amyloid precursor protein complex. Cousins SL, et al. J Neurochem, 2013 Sep. PMID 23621516
    4. Neto1 is an auxiliary subunit of native synaptic kainate receptors. Tang M, et al. J Neurosci, 2011 Jul 6. PMID 21734292, Free PMC Article
    5. Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning. Ng D, et al. PLoS Biol, 2009 Feb 24. PMID 19243221, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NETO1 and Gluk1 specifically promote dendritic growth of interneurons in the visual cortex.
      Title: Development of Cortical Pyramidal Cell and Interneuronal Dendrites: a Role for Kainate Receptor Subunits and NETO1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ionotropic glutamate receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ionotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterograde axonal transport of neurotransmitter receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in memory ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neurotransmitter receptor localization to postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of excitatory postsynaptic potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within receptor localization to synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of long-term neuronal synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynaptic neurotransmitter receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in visual learning ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in excitatory synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    neuropilin and tolloid-like protein 1
    Names
    neuropilin (NRP) and tolloid (TLL)-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107371.1 → NP_001100841.1  neuropilin and tolloid-like protein 1 precursor

      See identical proteins and their annotated locations for NP_001100841.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474021
      UniProtKB/TrEMBL
      A6K5M8, D4AAD6
      Related
      ENSRNOP00000019384.4, ENSRNOT00000019384.6
      Conserved Domains (2) summary
      cd00041
      Location:51 → 154
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cl00104
      Location:291 → 326
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      81905455..82028730
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255035.5 → XP_006255097.1  neuropilin and tolloid-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006255097.1

      UniProtKB/TrEMBL
      A6K5M8, D4AAD6
      Conserved Domains (2) summary
      cd00041
      Location:51 → 154
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cl00104
      Location:291 → 326
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    2. XM_039096765.2 → XP_038952693.1  neuropilin and tolloid-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A6K5M8, D4AAD6
      Conserved Domains (2) summary
      cd00041
      Location:51 → 154
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cl00104
      Location:291 → 326
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    3. XM_039096766.2 → XP_038952694.1  neuropilin and tolloid-like protein 1 isoform X2

      Conserved Domains (2) summary
      cd00041
      Location:51 → 154
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cl00104
      Location:158 → 193
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    4. XM_063277287.1 → XP_063133357.1  neuropilin and tolloid-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A6K5M8, D4AAD6

    5. XM_063277288.1 → XP_063133358.1  neuropilin and tolloid-like protein 1 isoform X5

    6. XM_039096769.2 → XP_038952697.1  neuropilin and tolloid-like protein 1 isoform X7

      Conserved Domains (1) summary
      cd00041
      Location:51 → 154
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

    7. XM_008772133.4 → XP_008770355.1  neuropilin and tolloid-like protein 1 isoform X6

      Conserved Domains (1) summary
      cd00041
      Location:51 → 154
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

    8. XM_039096768.2 → XP_038952696.1  neuropilin and tolloid-like protein 1 isoform X4

      Conserved Domains (2) summary
      cl00049
      Location:16 → 90
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cl00104
      Location:95 → 130
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    9. XM_039096767.1 → XP_038952695.1  neuropilin and tolloid-like protein 1 isoform X3

      Conserved Domains (2) summary
      cd00041
      Location:25 → 111
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cl00104
      Location:116 → 151
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    RNA

    1. XR_005496025.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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