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    Bora bora, aurora kinase A activator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306102, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Boraprovided by RGD
    Official Full Name
    bora, aurora kinase A activatorprovided by RGD
    Primary source
    RGD:1309522
    See related
    EnsemblRapid:ENSRNOG00000024798 AllianceGenome:RGD:1309522
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309522
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be involved in regulation of mitotic nuclear division; regulation of mitotic spindle organization; and regulation of protein localization. Predicted to be located in meiotic spindle. Predicted to be active in cytoplasm and nucleus. Orthologous to human BORA (BORA aurora kinase A activator). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 94.3), Spleen (RPKM 65.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bora in Genome Data Viewer
    Location:
    15q21
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (82205467..82243499)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (75797624..75835599)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (83442217..83463737)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097059 Neighboring gene mitotic spindle organizing protein 1 Neighboring gene Spi-C transcription factor, pseudogene 2 Neighboring gene DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease Neighboring gene progesterone immunomodulatory binding factor 1 Neighboring gene KLF transcription factor 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Bora regulates meiotic spindle assembly and cell cycle during mouse oocyte meiosis. Zhai R, et al. Mol Reprod Dev, 2013 Jun. PMID 23610072
    2. Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery. Macůrek L, et al. Nature, 2008 Sep 4. PMID 18615013
    3. Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora. Chan EH, et al. Chromosoma, 2008 Oct. PMID 18521620, Free PMC Article
    4. Mitotic activation of the kinase Aurora-A requires its binding partner Bora. Hutterer A, et al. Dev Cell, 2006 Aug. PMID 16890155
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitotic nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic nuclear division ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic spindle organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in meiotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein aurora borealis

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013997.1 → NP_001014019.1  protein aurora borealis

      See identical proteins and their annotated locations for NP_001014019.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088204
      UniProtKB/Swiss-Prot
      Q5M864
      UniProtKB/TrEMBL
      A6HU54
      Related
      ENSRNOP00000035098.3, ENSRNOT00000039344.6
      Conserved Domains (1) summary
      pfam15280
      Location:8 → 207
      BORA_N; Protein aurora borealis N-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      82205467..82243499
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093376.2 → XP_038949304.1  protein aurora borealis isoform X2

      UniProtKB/TrEMBL
      A6HU54
      Related
      ENSRNOP00000083042.2, ENSRNOT00000102440.2
      Conserved Domains (1) summary
      pfam15280
      Location:8 → 207
      BORA_N; Protein aurora borealis N-terminus

    2. XM_039093375.2 → XP_038949303.1  protein aurora borealis isoform X1

      UniProtKB/Swiss-Prot
      Q5M864
      UniProtKB/TrEMBL
      A6HU54
      Conserved Domains (1) summary
      pfam15280
      Location:8 → 207
      BORA_N; Protein aurora borealis N-terminus

    3. XM_039093377.2 → XP_038949305.1  protein aurora borealis isoform X3

    RNA

    1. XR_005493734.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5M864.1 GenPept UniProtKB/Swiss-Prot:Q5M864

    Gene LinkOut

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