Rel REL proto-oncogene, NF-kB subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Relprovided by RGD
Official Full Name: REL proto-oncogene, NF-kB subunitprovided by RGD
Primary source: RGD:1311231
See related: EnsemblRapid:ENSRNOG00000054437 AllianceGenome:RGD:1311231
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables sequence-specific DNA binding activity. Predicted to be involved in several processes, including intracellular signaling cassette; positive regulation of canonical NF-kappaB signal transduction; and regulation of gene expression. Predicted to act upstream of or within positive regulation of DNA-templated transcription and positive regulation of interleukin-12 production. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human REL (REL proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 85.0), Thymus (RPKM 42.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (101891238..101922324, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (97690105..97721194, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (108490794..108517582, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that C-rel binding on the interleukin-2 (IL-2) promoter region declined in the aged CD4+T cells.
Title: Decreased c-rel activation contributes to aberrant interleukin-2 expression in CD4(+)T cells of aged rats.
Expression of p65 and c-Rel implies that these subunits of NF-kappaB appear to contribute to the mechanisms of brain adaptation to severe hypoxia.
Title: [Pattern of neuronal expression of transcription factors NF-kappaB under different modes of hypobaric hypoxia].
PACAP promotes both survival and neuritogenesis in PC12 cells by activating NF-kappaB pathway, most likely via classical and alternative signaling cascades involving ERK1/2 kinases, Ca(2+), and c-Rel/p52 dimers.
Title: Pituitary adenylate cyclase-activating polypeptide (PACAP) promotes both survival and neuritogenesis in PC12 cells through activation of nuclear factor κB (NF-κB) pathway: involvement of extracellular signal-regulated kinase (ERK), calcium, and c-REL.
Short-term magnesium deficiency upregulates ceramide synthase in cardiovascular tissues, releasing cytokines and activation NFkappaB(relA/cRel).
Title: Short-term magnesium deficiency upregulates ceramide synthase in cardiovascular tissues and cells: cross-talk among cytokines, Mg2+, NF-κB, and de novo ceramide.
c-Rel is a reasonable phosphorylation target of PKA-Cbeta; the transcriptional activity of c-Rel is stimulated by PKA-Cbeta possibly through the interaction with p300/CBP
Title: Stimulation of c-Rel transcriptional activity by PKA catalytic subunit beta.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in non-canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to cytokine	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: proto-oncogene c-Rel

Names: reticuloendotheliosis oncogene; v-rel avian reticuloendotheliosis viral oncogene homolog; v-rel reticuloendotheliosis viral oncogene homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001421314.1 → NP_001408243.1 proto-oncogene c-Rel

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

A0A8I6ABJ7

Related

ENSRNOP00000072332.3, ENSRNOT00000081077.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

101891238..101922324 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039092882.2 → XP_038948810.1 proto-oncogene c-Rel isoform X1

UniProtKB/TrEMBL

A0A8I5XW27, F1M5R1

Related

ENSRNOP00000089353.2, ENSRNOT00000100608.2

Conserved Domains (2) summary

cd07933
Location:8 → 179

RHD-n_c-Rel; N-terminal sub-domain of the Rel homology domain (RHD) of c-Rel

pfam16179
Location:187 → 282

RHD_dimer; Rel homology dimerization domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001107243.2: Suppressed sequence

Description

NM_001107243.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.